C 反应蛋白、主观衰老与心血管疾病事件：一个中介模型。
C-Reactive Protein, Subjective Aging, and Incident Cardiovascular Disease: A Mediation Model.
机构信息
Department of Human Development and Family Science, University of Missouri, Columbia, Missouri, USA.
出版信息
J Gerontol B Psychol Sci Soc Sci. 2022 Sep 1;77(9):1654-1658. doi: 10.1093/geronb/gbac051.
OBJECTIVES
Negative self-perceptions of aging (SPA) and an older subjective age are associated with a greater likelihood of cardiovascular disease. We predicted that C-reactive protein (CRP), a marker of stress-related inflammation, would mediate this relation.
METHOD
Data from up to 6 602 participants ages 50-101 in the Health and Retirement Study (2008-2018) were analyzed using logistic regressions with mediation. Subjective aging was assessed in 2008 or 2010, CRP was assessed 2 years later, and diagnosis of heart disease or stroke was assessed in the years from CRP measurement to 2018.
RESULTS
Significant indirect effects occurred in all models, indicating that negative SPA and older subjective age are associated with a greater likelihood of heart disease and stroke through elevated levels of the inflammatory marker CRP.
DISCUSSION
These findings suggest that psychological factors such as subjective aging impact cardiovascular health through physiological mechanisms, specifically markers of inflammation.
目的
负面的衰老自我认知（SPA）和较老的主观年龄与心血管疾病的可能性增加有关。我们预测，C 反应蛋白（CRP），一种应激相关炎症的标志物，将介导这种关系。
方法
使用具有中介作用的逻辑回归分析了健康与退休研究（2008-2018 年）中最多 6602 名年龄在 50-101 岁的参与者的数据。主观年龄在 2008 年或 2010 年进行评估，CRP 在两年后进行评估，心脏病或中风的诊断在 CRP 测量后的几年内进行评估至 2018 年。
结果
所有模型均出现显著的间接效应，表明负面 SPA 和较老的主观年龄通过炎症标志物 CRP 水平升高与心脏病和中风的可能性增加有关。
讨论
这些发现表明，心理因素如主观年龄通过生理机制，特别是炎症标志物，影响心血管健康。
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