Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China.
Shandong Institute for Product Quality Inspection, Jinan 250100, China.
Chin J Nat Med. 2022 Feb;20(2):155-160. doi: 10.1016/S1875-5364(21)60103-6.
Three new ursane-type triterpenoids, 3-oxours-12-en-20, 28-olide (1), 3β-hydroxyurs-12-en-20, 28-olide (2) and 3β-hydroxyurs-11, 13(18)-dien-20, 28-olide (3), were isolated from a potent anti-inflammatory and antibacterial fraction of the ethanolic extract of Rosmarinus officinalis. Their structures were elucidated by a combination of extensive 1D- and 2D-NMR experiments, MS data and comparisons with literature reports. Compounds 1-3 exhibited significantly inhibitory effects on nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 macrophages, but no antibacterial activity was found at a concentration of 128 μg·mL.
3-氧代乌苏烷-12-烯-20,28-内酯（1）、3β-羟基乌苏烷-12-烯-20,28-内酯（2）和 3β-羟基乌苏烷-11,13(18)-二烯-20,28-内酯（3）。通过广泛的 1D 和 2D-NMR 实验、MS 数据以及与文献报道的比较，确定了它们的结构。化合物 1-3 对脂多糖激活的小鼠 RAW264.7 巨噬细胞中一氧化氮的产生具有显著的抑制作用，但在 128 μg·mL 的浓度下没有发现抗菌活性。
