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根据阿尔茨海默病的AT(N)研究框架，对患有轻度认知障碍且脑脊液生物标志物谱不同的成年人进行脑萎缩和临床特征分析。

Brain Atrophy and Clinical Characterization of Adults With Mild Cognitive Impairment and Different Cerebrospinal Fluid Biomarker Profiles According to the AT(N) Research Framework of Alzheimer's Disease.

作者信息

Rivas-Fernández Miguel Ángel, Lindín Mónica, Zurrón Montserrat, Díaz Fernando, Aldrey-Vázquez José Manuel, Pías-Peleteiro Juan Manuel, Vázquez-Vázquez Laura, Pereiro Arturo Xosé, Lojo-Seoane Cristina, Nieto-Vieites Ana, Galdo-Álvarez Santiago

机构信息

Department of Clinical Psychology and Psychobiology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.

Neurology Service, Santiago Clinic Hospital (CHUS), Santiago de Compostela, Spain.

出版信息

Front Hum Neurosci. 2022 Feb 25;16:799347. doi: 10.3389/fnhum.2022.799347. eCollection 2022.

DOI:10.3389/fnhum.2022.799347
PMID:35280203
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8914376/
Abstract

INTRODUCTION

This study aimed to evaluate, in adults with mild cognitive impairment (MCI), the brain atrophy that may distinguish between three AT(N) biomarker-based profiles, and to determine its clinical value.

METHODS

Structural MRI (sMRI) was employed to evaluate the volume and cortical thickness differences in MCI patients with different AT(N) profiles, namely, A-T-(N)-: ; A+T-(N)-: ; and A+T+(N)+: . Sensitivity and specificity of these changes were also estimated.

RESULTS

An initial atrophy in medial temporal lobe (MTL) areas was found in the A+T-(N)- and A+T+(N)+ groups, spreading toward the parietal and frontal regions in A+T+(N)+ patients. These structural changes allowed distinguishing AT(N) profiles within the AD continuum; however, the profiles and their pattern of neurodegeneration were unsuccessful to determine the current clinical status.

CONCLUSION

sMRI is useful in the determination of the specific brain structural changes of AT(N) profiles along the AD continuum, allowing differentiation between MCI adults with or without pathological AD biomarkers.

摘要

引言

本研究旨在评估轻度认知障碍（MCI）成人中可能区分基于三种AT（N）生物标志物的不同特征的脑萎缩情况，并确定其临床价值。

方法

采用结构磁共振成像（sMRI）评估具有不同AT（N）特征的MCI患者的体积和皮质厚度差异，即A-T-（N）-；A+T-（N）-；以及A+T+（N）+。还估计了这些变化的敏感性和特异性。

结果

在A+T-（N）-和A+T+（N）+组中发现内侧颞叶（MTL）区域最初出现萎缩，在A+T+（N）+患者中向顶叶和额叶区域扩展。这些结构变化有助于在AD连续体中区分AT（N）特征；然而，这些特征及其神经退行性变模式未能确定当前的临床状态。

结论

sMRI有助于确定AD连续体中AT（N）特征的特定脑结构变化，能够区分有或没有病理性AD生物标志物的MCI成人。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03e2/8914376/dcff9a22e655/fnhum-16-799347-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03e2/8914376/fac364b827c7/fnhum-16-799347-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03e2/8914376/dcff9a22e655/fnhum-16-799347-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03e2/8914376/fac364b827c7/fnhum-16-799347-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03e2/8914376/dcff9a22e655/fnhum-16-799347-g002.jpg

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