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2,3'-螺二吲哚-2'-酮的高效合成及其对HeLa细胞线粒体损伤的初步评估

Efficient Synthesis of 2,3'-Spirobi (Indolin)-2'-Ones and Preliminary Evaluation of Their Damage to Mitochondria in HeLa Cells.

作者信息

Li Huajie, Yu Zhenjie, Sun Haoyi, Liu Bo, Wang Xin, Shao Zhe, Wang Meiling, Xie Weilin, Yao Xingang, Yao Qingqiang, Zhi Ying

机构信息

School of Pharmacy and Pharmaceutical Sciences, Shandong First Medical University, Jinan, China.

Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, China.

出版信息

Front Pharmacol. 2022 Feb 23;12:821518. doi: 10.3389/fphar.2021.821518. eCollection 2021.

DOI:10.3389/fphar.2021.821518
PMID:35280257
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8904893/
Abstract

A novel formal (4 + 1) annulation between -(-chloromethyl)aryl amides and 3-chlorooxindoles through generated aza--QMs with 3-chlorooxindoles is reported for the synthesis of a series of 2,3'-spirobi (indolin)-2'-ones in high yields. Under structured illumination microscopy, compound is found to change the mitochondrial morphology and induce mitophagy pathway, which might then trigger mitophagy in cancer cells.

摘要

据报道，通过生成的氮杂-醌亚甲基与3-氯氧化吲哚，实现了-（-氯甲基）芳基酰胺与3-氯氧化吲哚之间一种新型的形式上的（4 + 1）环化反应，用于高产率合成一系列2,3'-螺二（吲哚啉）-2'-酮。在结构光照显微镜下，发现化合物会改变线粒体形态并诱导线粒体自噬途径，进而可能触发癌细胞中的线粒体自噬。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecce/8904893/b243645ce94a/fphar-12-821518-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecce/8904893/1041419de772/fphar-12-821518-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecce/8904893/bef0d2d4cc8a/fphar-12-821518-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecce/8904893/eb260e70ab84/fphar-12-821518-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecce/8904893/b243645ce94a/fphar-12-821518-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecce/8904893/1041419de772/fphar-12-821518-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecce/8904893/bef0d2d4cc8a/fphar-12-821518-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecce/8904893/eb260e70ab84/fphar-12-821518-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecce/8904893/b243645ce94a/fphar-12-821518-g002.jpg

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Understanding the tonifying and the detoxifying properties of Chinese medicines from their impacts on gut microbiota and host metabolism: a case study with four medicinal herbs in experimental colitis rat model.从对肠道微生物群和宿主代谢的影响理解中药的补益和解毒特性：以实验性结肠炎大鼠模型中的四种草药为例
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