自身免疫性疾病中 Th17 和调节性 T 细胞的代谢特征。

Department of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, China.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Front Immunol. 2022 Feb 25;13:828191. doi: 10.3389/fimmu.2022.828191. eCollection 2022.

The abnormal number and functional deficiency of immune cells are the pathological basis of various diseases. Recent years, the imbalance of Th17/regulatory T (Treg) cell underlies the occurrence and development of inflammation in autoimmune diseases (AID). Currently, studies have shown that material and energy metabolism is essential for maintaining cell survival and normal functions and the altered metabolic state of immune cells exists in a variety of AID. This review summarizes the biology and functions of Th17 and Treg cells in AID, with emphasis on the advances of the roles and regulatory mechanisms of energy metabolism in activation, differentiation and physiological function of Th17 and Treg cells, which will facilitate to provide targets for the treatment of immune-mediated diseases.

免疫细胞数量和功能异常是各种疾病的病理基础。近年来，辅助性 T 细胞 17（Th17）/调节性 T（Treg）细胞失衡与自身免疫性疾病（AID）的发生发展有关。目前的研究表明，物质和能量代谢对于维持细胞存活和正常功能至关重要，免疫细胞的代谢状态改变存在于多种 AID 中。本综述总结了 Th17 和 Treg 细胞在 AID 中的生物学和功能，重点介绍了能量代谢在 Th17 和 Treg 细胞的激活、分化和生理功能中的作用和调节机制的研究进展，这将有助于为免疫介导性疾病的治疗提供新靶点。