Deepashree Pramod Gujjar, Madhushankari Gunjiganur Shankarappa, Nandini Doddabasavaiah Basavapur, Priya Nagur Karibasappa, Ashwini Ramakrishna, Shruthy Ramappa
Department of Oral Pathology and Microbiology, Bapuji Dental College and Hospital, Davangere, Karnataka, India.
Department of Oral Pathology and Microbiology, College of Dental Sciences, Davangere, Karnataka, India.
J Oral Maxillofac Pathol. 2021 Sep-Dec;25(3):457-462. doi: 10.4103/jomfp.jomfp_439_20. Epub 2022 Jan 11.
Pregnancy is a physiological condition in which the maternal environment undergoes many changes. Serum uric acid (UA) levels have been used for the early diagnosis of preeclampsia, predictor of reduced birth weight and fetal outcome. UA is also expressed in saliva, and collection of saliva sample is a noninvasive method which will be more acceptable by the patients.
The present study aimed to estimate and compare serum and salivary UA levels in age-matched healthy nonpregnant and healthy pregnant women at different trimesters longitudinally.
Forty female participants with age ranging between 20 and 38 years comprised the study population. The study group consisted of 20 healthy nonpregnant women (controls) and an equal number of confirmed cases of healthy pregnant women in the first trimester (cases). The cases were followed in their second and third trimesters for the sample collection.
Both serum and salivary UA levels were significantly reduced in the first trimester of pregnancy than the controls. In the second and third trimesters, the values of serum and salivary UA levels gradually increased and gained values similar to that of nonpregnant women. Salivary UA levels showed a highly significant positive correlation with serum levels in both controls and cases.
Salivary estimation, being a noninvasive procedure, is easily accepted by the patients and carries minimal risk of exposure to the blood-borne pathogens compared to serum estimation. Our findings warrant the use of saliva instead of blood for UA estimation.
妊娠是一种生理状态，在此期间母体环境会发生许多变化。血清尿酸（UA）水平已被用于子痫前期的早期诊断、出生体重降低和胎儿结局的预测指标。尿酸也存在于唾液中，采集唾液样本是一种非侵入性方法，患者更容易接受。
本研究旨在纵向评估和比较年龄匹配的健康未孕女性和不同孕期的健康孕妇血清和唾液中的尿酸水平。
40名年龄在20至38岁之间的女性参与者构成了研究人群。研究组由20名健康未孕女性（对照组）和数量相等的确诊为孕早期的健康孕妇（病例组）组成。对病例组在孕中期和孕晚期进行样本采集。
孕期第一个月血清和唾液尿酸水平均显著低于对照组。在孕中期和孕晚期，血清和唾液尿酸水平逐渐升高，接近未孕女性的水平。在对照组和病例组中，唾液尿酸水平与血清水平均呈现高度显著的正相关。
唾液检测作为一种非侵入性检测方法，易为患者接受，与血清检测相比，接触血源性病原体的风险极小。我们的研究结果支持使用唾液而非血液进行尿酸检测。
