Riis Jenna L, Bryce Crystal I, Matin Marla J, Stebbins John L, Kornienko Olga, Huisstede Lauren van, Granger Douglas A
Institute for Interdisciplinary Salivary Bioscience Research, University of California at Irvine, Irvine, CA 92697, USA.
T. Denny Sanford School of Social & Family Dynamics, Arizona State University, Tempe, AZ 85287, USA.
Biomark Med. 2018 Jun;12(6):583-596. doi: 10.2217/bmm-2017-0336. Epub 2018 Jun 6.
Serum uric acid (UA) is associated with many health conditions, including kidney, cardiovascular, and metabolic disorders. We examined the validity and stability of salivary UA as a noninvasive measure of serum UA.
MATERIALS & METHODS: Using serum and salivary UA data from healthy adults (n = 99), we examined the UA serum-saliva correlation, and UA associations with adiponectin and C-reactive protein. Using longitudinal data from young adults (n = 182), we examined salivary UA stability.
We found robust positive serum-saliva correlations for UA. UA and adiponectin were inversely related in serum and saliva. Salivary UA was relatively stable; 62-66% of variance could be attributed to a latent trait-like component.
Salivary UA may be an important biomarker indexing health and disease risk.
血清尿酸（UA）与许多健康状况相关，包括肾脏、心血管和代谢紊乱。我们研究了唾液尿酸作为血清尿酸非侵入性测量指标的有效性和稳定性。
利用健康成年人（n = 99）的血清和唾液尿酸数据，我们研究了尿酸的血清-唾液相关性，以及尿酸与脂联素和C反应蛋白的关联。利用年轻人（n = 182）的纵向数据，我们研究了唾液尿酸的稳定性。
我们发现尿酸的血清-唾液相关性很强且呈正相关。尿酸与脂联素在血清和唾液中呈负相关。唾液尿酸相对稳定；62%-66%的变异可归因于类似潜在特质的成分。
唾液尿酸可能是一个重要的生物标志物，可用于指示健康和疾病风险。
