Bampidis Vasileios, Azimonti Giovanna, Bastos Maria de Lourdes, Christensen Henrik, Dusemund Birgit, Fašmon Durjava Mojca, Kouba Maryline, López-Alonso Marta, López Puente Secundino, Marcon Francesca, Mayo Baltasar, Pechová Alena, Petkova Mariana, Ramos Fernando, Sanz Yolanda, Villa Roberto Edoardo, Woutersen Ruud, Anguita Montserrat, Brozzi Rosella, Galobart Jaume, Manini Paola, Tarrés-Call Jordi, Pettenati Elisa
EFSA J. 2022 Mar 7;20(3):e07153. doi: 10.2903/j.efsa.2022.7153. eCollection 2022 Mar.
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of disodium 5'-inosinate (IMP) produced by fermentation using KCCM 80235 as a sensory additive (flavouring compound) in feed and water for drinking for all animal species. The production strain is genetically modified, and it is resistant to streptomycin. No viable cells were detected in the final product. However, uncertainties remained on the genetic basis of the streptomycin resistance and on the possible presence of recombinant DNA from the production strain in the final product. Therefore, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) could not conclude on the safety of the additive for the target species, consumers, users and the environment. Moreover, the FEEDAP Panel reiterated its previous concerns on the safety of the use of IMP in water for drinking due to hygienic reasons. The Panel concluded that the additive is efficacious to contribute to the flavour of feed and water for drinking.
应欧盟委员会的要求，欧洲食品安全局被要求就使用KCCM 80235通过发酵生产的5'-肌苷酸二钠（IMP）作为所有动物物种饲料和饮用水中的感官添加剂（调味化合物）的安全性和有效性发表科学意见。生产菌株经过基因改造，对链霉素具有抗性。在最终产品中未检测到活细胞。然而，链霉素抗性的遗传基础以及最终产品中可能存在来自生产菌株的重组DNA仍存在不确定性。因此，动物饲料添加剂和产品或物质专家小组（FEEDAP）无法就该添加剂对目标物种、消费者、使用者和环境的安全性得出结论。此外，FEEDAP小组重申了其先前因卫生原因对在饮用水中使用IMP的安全性的担忧。该小组得出结论，该添加剂对改善饲料和饮用水的风味有效。
