Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
Int J Gynecol Pathol. 2023 Mar 1;42(2):176-181. doi: 10.1097/PGP.0000000000000854. Epub 2022 Mar 11.
While angiosarcoma metastatic to the ovary is rare, metastatic angiosarcoma to an ovarian tumor has never been reported in the literature, so far. We report a case of a 61-yr-old postmenopausal woman with history of breast cancer, presenting with metastatic angiosarcoma to an ovarian Brenner tumor. Initially at the frozen section examination, on limited sampling, and without knowledge of the patient's history, a diagnosis of at least proliferating Brenner tumor was rendered. Upon review of permanent sections, an intermixed angiosarcoma component was identified within Brenner tumor. Tumor to ovarian tumor metastasis is a rare phenomenon, with only 18 cases reported in the last 50 yr. It poses diagnostic challenges during sampling and histopathologic interpretation. Detailed clinical history, careful gross examination and sampling are important to recognize the separate tumor components.
虽然血管肉瘤转移到卵巢很少见，但到目前为止，转移性血管肉瘤转移到卵巢肿瘤在文献中从未报道过。我们报告了一例 61 岁绝经后妇女，有乳腺癌病史，表现为卵巢 Brenner 肿瘤转移性血管肉瘤。最初在冷冻切片检查时，在有限的取样和不知道患者病史的情况下，至少做出了增殖性 Brenner 肿瘤的诊断。在复查石蜡切片时，在 Brenner 肿瘤内发现了混合的血管肉瘤成分。肿瘤到卵巢肿瘤的转移是一种罕见现象，在过去 50 年中仅报告了 18 例。在取样和组织病理学解释过程中，它会带来诊断挑战。详细的临床病史、仔细的大体检查和取样对于识别不同的肿瘤成分很重要。
