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0.5%噻吗洛尔溶液局部治疗复杂型婴儿血管瘤成功:病例报告

Complicated Infantile Hemangioma Successfully Treated with Topical Timolol 0.5% Solution: A Case Report.

作者信息

Borkar Nitin, Sharma Aarti, Hota Dayanand

机构信息

AIIMS, Raipur, Chhattisgarh, India.

出版信息

J Cutan Aesthet Surg. 2021 Oct-Dec;14(4):440-442. doi: 10.4103/JCAS.JCAS_69_20.

DOI:10.4103/JCAS.JCAS_69_20
PMID:35283589
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8906260/
Abstract

Infantile hemangiomas (IHs) are common benign lesions involving most part of the body. It can regress spontaneously but these hemangiomas should be treated early on course of evolution to prevent further complications. Different treatment options are available for its management. Topical timolol 0.5% solution available as eye drops or gel can be used as first-line therapy even in complicated IH. We have successfully treated a large complicated facial IH by using topical timolol 0.5% solution.

摘要

婴儿血管瘤(IHs)是常见的良性病变,可累及身体大部分部位。它可自发消退,但这些血管瘤在演变过程中应尽早治疗,以防止进一步的并发症。其治疗有多种选择。0.5%的噻吗洛尔滴眼液或凝胶制剂可作为一线治疗,即使是复杂的婴儿血管瘤也适用。我们使用0.5%的噻吗洛尔溶液成功治疗了一例大型复杂面部婴儿血管瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b84d/8906260/064a4c2d2cbd/JCAS-14-440-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b84d/8906260/456bb23393ca/JCAS-14-440-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b84d/8906260/48877806b695/JCAS-14-440-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b84d/8906260/064a4c2d2cbd/JCAS-14-440-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b84d/8906260/456bb23393ca/JCAS-14-440-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b84d/8906260/48877806b695/JCAS-14-440-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b84d/8906260/064a4c2d2cbd/JCAS-14-440-g003.jpg

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本文引用的文献

1
Topical Timolol Vs. Oral Propranolol for the Treatment of Superficial Infantile Hemangiomas.局部用噻吗洛尔与口服普萘洛尔治疗浅表性婴儿血管瘤的对比研究
Front Oncol. 2018 Dec 18;8:605. doi: 10.3389/fonc.2018.00605. eCollection 2018.
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Effect of topical timolol on response rate and adverse events in infantile hemangioma: a meta-analysis.局部用噻吗洛尔对婴儿血管瘤反应率和不良事件的影响:荟萃分析。
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Infantile haemangioma.婴儿血管瘤。
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Topical Timolol Maleate 0.5% for Infantile Hemangioma: Its Effectiveness Compared to Ultrapotent Topical Corticosteroids - A Single-Center Experience of 278 Cases.0.5%马来酸噻吗洛尔局部用药治疗婴幼儿血管瘤:与超强效局部用皮质类固醇激素相比的疗效——278例单中心经验
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Topical Timolol Maleate Treatment of Infantile Hemangiomas.马来酸噻吗洛尔局部治疗婴幼儿血管瘤
Pediatrics. 2016 Sep;138(3). doi: 10.1542/peds.2016-0355. Epub 2016 Aug 15.
7
Treatment of infantile haemangiomas: recommendations of a European expert group.婴儿血管瘤的治疗:欧洲专家组的建议
Eur J Pediatr. 2015 Jul;174(7):855-65. doi: 10.1007/s00431-015-2570-0. Epub 2015 May 29.
8
Evaluation of β-blocker gel and effect of dosing volume for topical delivery.β受体阻滞剂凝胶的评估及局部给药剂量体积的影响。
J Pharm Sci. 2015 May;104(5):1721-31. doi: 10.1002/jps.24390. Epub 2015 Feb 18.
9
Local administration of β-blockers for infantile hemangiomas: a systematic review and meta-analysis.β受体阻滞剂局部给药治疗婴幼儿血管瘤:一项系统评价与荟萃分析。
Ann Plast Surg. 2015 Feb;74(2):256-62. doi: 10.1097/SAP.0000000000000390.
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Propranolol and infantile hemangiomas four years later: a systematic review.四年后的普萘洛尔与婴儿血管瘤:一项系统综述
Pediatr Dermatol. 2013 Mar-Apr;30(2):182-91. doi: 10.1111/pde.12089. Epub 2013 Feb 14.