Rashid Sameera, Akhtar Mohammed
Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar.
Saudi J Med Med Sci. 2022 Jan-Apr;10(1):72-76. doi: 10.4103/sjmms.sjmms_315_21. Epub 2022 Jan 17.
Uterine adenosarcoma is usually a low-grade neoplasm with a mixed benign epithelial component and malignant stroma, commonly found in postmenopausal women. In the presence of sarcomatous overgrowth, it has been shown to have poor prognosis. Uterine adenosarcoma with sarcomatous overgrowth and rhabdoid features is extremely rare. We report here a case of a 28-year-old female who was found to have adenosarcoma with sarcomatous overgrowth with extensive rhabdoid features. The tumor had metastasized to the pelvis, omentum, iliac, and obturator lymph nodes. She was lost to follow-up for 10 months, after which she presented with recurrent tumor at the hysterectomy site. She was started on palliative chemoradiotherapy, on which she progressed but later experienced drug toxicity, became cachectic, and was unwilling to continue chemotherapy. There are a few cases of adenosarcoma with sarcomatous overgrowth reported in young women and only two cases with rhabdoid features. Based on this report, adenosarcoma with sarcomatous overgrowth and rhabdoid features appears to be an extremely aggressive tumor with poor prognosis.
子宫腺肉瘤通常是一种低级别肿瘤，由良性上皮成分和恶性间质混合组成，常见于绝经后女性。当出现肉瘤样过度生长时，其预后较差。伴有肉瘤样过度生长及横纹肌样特征的子宫腺肉瘤极为罕见。我们在此报告一例28岁女性，她被发现患有伴有广泛横纹肌样特征的肉瘤样过度生长的腺肉瘤。肿瘤已转移至盆腔、大网膜、髂骨和闭孔淋巴结。她失访了10个月，之后在子宫切除部位出现肿瘤复发。她开始接受姑息性放化疗，病情进展，但后来出现药物毒性，身体消瘦，且不愿继续化疗。在年轻女性中报道过几例伴有肉瘤样过度生长的腺肉瘤，仅有两例具有横纹肌样特征。基于本报告，伴有肉瘤样过度生长及横纹肌样特征的腺肉瘤似乎是一种极具侵袭性且预后不良的肿瘤。
