Peng Liling, Feng Jing, Ma Di, Xu Xiaowen, Gao Xin
Shanghai Universal Medical Imaging Diagnostic Center, Shanghai, China.
The Fifth People's Hospital of Jinan, Jinan, China.
Front Aging Neurosci. 2022 Feb 25;14:834145. doi: 10.3389/fnagi.2022.834145. eCollection 2022.
Subjective cognitive decline (SCD) was considered to be the preclinical stage of Alzheimer's disease (AD). However, less is known about the altered rich-club organizations of the morphological networks in individuals with SCD.
This study included 53 individuals with SCD and 54 well-matched healthy controls (HC) from the Alzheimer's disease Neuroimaging Initiative (ADNI) database. Individual-level brain morphological networks were constructed by estimating the Jensen-Shannon distance-based similarity in the distribution of regional gray matter volume. Rich-club properties were then detected, followed by statistical comparison.
The characteristic rich-club organization of morphological networks (normalized rich-club coefficients > 1) was observed for both the SCD and HC groups under a range of thresholds. The SCD group showed a reduced normalized rich-club coefficient compared with the HC group. The SCD group exhibited the decreased strength and degree of rich-club connections than the HC group (strength: HC = 79.93, SCD = 74.37, = 0.028; degree: HC = 85.28, SCD = 79.34, = 0.027). Interestingly, the SCD group showed an increased strength of local connections than the HC group (strength: HC = 1982.16, SCD = 2003.38, = 0.036).
Rich-club organization disturbances of morphological networks in individuals with SCD reveal a distinct pattern between the rich-club and peripheral regions. This altered rich-club organization pattern provides novel insights into the underlying mechanism of SCD and could be used to investigate prevention strategies at the preclinical stage of AD.
主观认知下降（SCD）被认为是阿尔茨海默病（AD）的临床前期。然而，对于SCD个体形态学网络中丰富俱乐部组织的改变了解较少。
本研究纳入了来自阿尔茨海默病神经影像倡议（ADNI）数据库的53名SCD个体和54名匹配良好的健康对照（HC）。通过估计基于詹森 - 香农距离的区域灰质体积分布相似性来构建个体水平的脑形态学网络。然后检测丰富俱乐部属性，随后进行统计比较。
在一系列阈值下，SCD组和HC组均观察到形态学网络的特征性丰富俱乐部组织（标准化丰富俱乐部系数>1）。与HC组相比，SCD组的标准化丰富俱乐部系数降低。SCD组的丰富俱乐部连接强度和度数均低于HC组（强度：HC = 79.93，SCD = 74.37，P = 0.028；度数：HC = 85.28，SCD = 79.34，P = 0.027）。有趣的是，与HC组相比，SCD组的局部连接强度增加（强度：HC = 1982.16，SCD = 2003.38，P = 0.036）。
SCD个体形态学网络的丰富俱乐部组织紊乱揭示了丰富俱乐部区域和周边区域之间的独特模式。这种改变的丰富俱乐部组织模式为SCD的潜在机制提供了新的见解，并可用于研究AD临床前期的预防策略。
