Tabatabaei Seyed Ali, Mansouri Abraham, Tarokh Ali, Chini Seyed Farshid
School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran, Iran.
Department of Mechanical Engineering, HCT, DBM, Dubai, UAE.
Eur Phys J Plus. 2022;137(3):312. doi: 10.1140/epjp/s13360-022-02519-8. Epub 2022 Mar 7.
Deoxyribonucleic acid (DNA) encodes all genetic information, and in genetic disorders, DNA sequencing is used as an effective diagnosis. Nanopore/slit is one of the recent and successful tools for DNA sequencing. Passage of DNA along the pores creates non-uniform ionic currents which creates non-uniform electric and magnetic fields, accordingly. Sensing the electric field is usually used for sequencing application. We suggest to use the magnetic field induced by pressure-driven ionic currents as a secondary signal. We systematically compared the induced magnetic field of nanopores and nanoslits with equal cross-sectional area. The 3D magnetic field is numerically obtained by solving the Poisson-Nernst-Planck, Ampere, and Navier-Stokes equations. As expected, the maximum value of the maximum magnetic flux occurs near the wall and inside the channel, and increasing the pressure gradient along the pore/slit increases the flowrate and magnetic field, consequently. At a given pressure difference across the pore/slit, nanopores are better than nanoslits in sensing the magnetic flux. For example, by applying 2 MPa across the pore/slit, the maximum magnetic flux density for nanopore, nanoslit and nanoslit are 1.10 pT, 1.08 pT and 0.45 pT, accordingly. Also, at a given flowrate across the pore/slit, nanoslits are the better choice. It should be noted the external magnetic fields as small as pico-Tesla are detectable and measurable in voltage/pressure driven electrokinetic flow slits.
脱氧核糖核酸（DNA）编码所有遗传信息，在遗传疾病中，DNA测序被用作一种有效的诊断方法。纳米孔/狭缝是近期成功用于DNA测序的工具之一。DNA沿着孔道通过时会产生不均匀的离子电流，相应地会产生不均匀的电场和磁场。检测电场通常用于测序应用。我们建议将压力驱动离子电流感应的磁场用作辅助信号。我们系统地比较了具有相同横截面积的纳米孔和纳米狭缝的感应磁场。通过求解泊松 - 能斯特 - 普朗克方程、安培方程和纳维 - 斯托克斯方程，数值计算得到三维磁场。正如预期的那样，最大磁通量的最大值出现在壁面附近和通道内部，并且沿着孔道/狭缝增加压力梯度会增加流速和磁场。在跨孔道/狭缝的给定压力差下，纳米孔在感应磁通量方面优于纳米狭缝。例如，在跨孔道/狭缝施加2兆帕压力时，纳米孔、纳米狭缝1和纳米狭缝2的最大磁通密度分别为1.10皮特斯拉、1.08皮特斯拉和0.45皮特斯拉。此外，在跨孔道/狭缝的给定流速下，纳米狭缝是更好的选择。应当指出，在电压/压力驱动的电动流狭缝中，可以检测和测量低至皮特斯拉的外部磁场。
