Touati Rabeb, Elngar Ahmed A
LR99ES10 Human Genetics Laboratory, Faculty of Medicine of Tunis (FMT), University of Tunis El Manar, Tunis, Tunisia.
BIOPOLE Society, 63 Av. Hbib Bourguiba, Tunis, Tunisia.
Beni Suef Univ J Basic Appl Sci. 2022;11(1):34. doi: 10.1186/s43088-022-00216-0. Epub 2022 Mar 7.
Coronaviruses, members of the Coronavirinae subfamily in the Coronaviridae family, are enveloped and positive-stranded RNA viruses that infect animals and humans, causing intestinal and respiratory infections. Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus, named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This disease appeared, for the first time (December 2019), in China and has spread quickly worldwide causing a large number of deaths. Considering the global threat, the World Health Organization (WHO) has declared, in March 2020, COVID-19 as a pandemic. Many studies suggest the great effect of the existing vaccines to protect against symptomatic cases of death by the COVID-19 virus. This paper, proposes to compare the main antigenic proteins sequences of the existing vaccines with Spike (S) protein of the SARS-CoV-2 genome. Our choice of S protein is justified by the major role that plays it in the receptor recognition and membrane fusion process based on an intelligent system. Herein, we focus on finding a correlation between S protein and compulsory vaccines in the countries that have a less death number by COVID-19 virus. In this work, we have used a combination of coding methods, signal processing, and bioinformatic techniques with the goal to localize the similar patterns between the S gene of the SARS-Cov-2 genome and 14 investigated vaccines.
A total of 8 similar sequences which have a size more than 6 amino acids were identified. Further, these comparisons propose that these segments can be implicated in the immune response against COVID-19, which may explain the wide variation by country in the severity of this viral threat.
Our in silico study suggests a possible protective effect of Poliovirus, HIB, Hepatitis B, PCV10, Measles, Mumps, and Rubella (MMR) vaccines against COVID-19.
冠状病毒是冠状病毒科冠状病毒亚科的成员，是包膜的正链RNA病毒，可感染动物和人类，引起肠道和呼吸道感染。2019冠状病毒病（COVID-19）由一种新型冠状病毒引起，名为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）。这种疾病于2019年12月首次在中国出现，并迅速在全球传播，导致大量死亡。鉴于全球威胁，世界卫生组织（WHO）于2020年3月宣布COVID-19为大流行病。许多研究表明，现有疫苗对预防COVID-19病毒导致的有症状死亡病例有很大作用。本文建议将现有疫苗的主要抗原蛋白序列与SARS-CoV-2基因组的刺突（S）蛋白进行比较。我们选择S蛋白是因为它在基于智能系统的受体识别和膜融合过程中发挥着重要作用。在此，我们专注于在COVID-19病毒死亡人数较少的国家中寻找S蛋白与强制疫苗之间的相关性。在这项工作中，我们结合了编码方法、信号处理和生物信息学技术，目的是定位SARS-CoV-2基因组的S基因与14种研究疫苗之间的相似模式。
共鉴定出8个长度超过6个氨基酸的相似序列。此外，这些比较表明这些片段可能与针对COVID-19的免疫反应有关，这可能解释了该病毒威胁严重程度在不同国家的广泛差异。
我们的计算机模拟研究表明，脊髓灰质炎疫苗、HIB疫苗、乙肝疫苗、PCV10疫苗、麻疹疫苗、腮腺炎疫苗和风疹（MMR）疫苗可能对COVID-19有保护作用。
