Laboratory of Clinical Virology, WHO Regional Reference Laboratory for Poliomyelitis and Measles for the EMR, Institut Pasteur de Tunis, University of Tunis El Manar, 13 place Pasteur, BP74 1002 le Belvédère, Tunis, Tunisia.
LR20IPT10 Laboratory of Virus, Host and Vectors, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia.
BMC Bioinformatics. 2021 Mar 26;22(1):163. doi: 10.1186/s12859-021-04045-3.
Coronavirus Disease 2019 (COVID-19) is a viral pandemic disease that may induce severe pneumonia in humans. In this paper, we investigated the putative implication of 12 vaccines, including BCG, OPV and MMR in the protection against COVID-19. Sequences of the main antigenic proteins in the investigated vaccines and SARS-CoV-2 proteins were compared to identify similar patterns. The immunogenic effect of identified segments was, then, assessed using a combination of structural and antigenicity prediction tools.
A total of 14 highly similar segments were identified in the investigated vaccines. Structural and antigenicity prediction analysis showed that, among the identified patterns, three segments in Hepatitis B, Tetanus, and Measles proteins presented antigenic properties that can induce putative protective effect against COVID-19.
Our results suggest a possible protective effect of HBV, Tetanus and Measles vaccines against COVID-19, which may explain the variation of the disease severity among regions.
2019 年冠状病毒病（COVID-19）是一种病毒性大流行疾病，可在人类中引起严重肺炎。在本文中，我们研究了 12 种疫苗（包括卡介苗、口服脊髓灰质炎疫苗和麻疹腮腺炎风疹联合疫苗）对 COVID-19 的可能保护作用。比较了研究疫苗和 SARS-CoV-2 蛋白的主要抗原蛋白的序列，以确定相似模式。然后，使用结构和抗原性预测工具的组合评估鉴定片段的免疫原性效应。
在研究的疫苗中总共鉴定出 14 个高度相似的片段。结构和抗原性预测分析表明，在鉴定出的模式中，乙型肝炎、破伤风和麻疹蛋白中的三个片段具有抗原特性，可诱导针对 COVID-19 的假定保护作用。
我们的结果表明乙型肝炎、破伤风和麻疹疫苗对 COVID-19 可能具有保护作用，这可以解释不同地区疾病严重程度的差异。
