Sharma Manoj B, Kap Özlem, Abdelmohsen Hend A M, Ashton Mark D, Harper Garry R, Firlak Melike, Aaltonen Jasmine E, Bolland Kerry A, Bragg Ryan, Deeley Sarah, Francis Ella, Kazi Nahin, Mapley Bethany L, Oikonomou Vasileios, Aljohani Amal D, Cheneler David, Kilic Volkan, Horzum Nesrin, Hardy John G
Department of Chemistry Lancaster University Lancaster LA1 4YB UK.
School of Engineering Lancaster University Lancaster LA1 4YW UK.
Glob Chall. 2023 Jul 5;7(8):2300002. doi: 10.1002/gch2.202300002. eCollection 2023 Aug.
The release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches is demonstrated in vitro. Tuning the composition of the pHEMA hydrogels enables preparation of robust microneedle patches with mechanical properties such that they would penetrate skin (insertion force of a single microneedle to be ≈40 N). Swelling experiments conducted at 20, 35, and 60 °C show temperature-dependent degrees of swelling and diffusion kinetics. Drug release from the pHEMA hydrogel-based microneedles is fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application for transdermal delivery of metformin for the treatment of aging, cancer, diabetes, etc.
体外实验展示了用于治疗癌症和糖尿病的药物二甲双胍从聚甲基丙烯酸羟乙酯（pHEMA）水凝胶基微针贴片中的释放情况。调节pHEMA水凝胶的组成能够制备出具有机械性能的坚固微针贴片，使其能够穿透皮肤（单个微针的插入力约为40 N）。在20、35和60°C下进行的溶胀实验表明溶胀程度和扩散动力学与温度有关。从pHEMA水凝胶基微针中的药物释放符合各种模型（例如零级、一级、二级）。这种pHEMA微针在经皮递送二甲双胍以治疗衰老、癌症、糖尿病等方面具有潜在应用。
