真核 B 族复制酶的核苷酸掺入及其对基因组稳定性的影响。
Ribonucleotide Incorporation by Eukaryotic B-Family Replicases and Its Implications for Genome Stability.
机构信息
Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA; email:
出版信息
Annu Rev Biochem. 2022 Jun 21;91:133-155. doi: 10.1146/annurev-biochem-032620-110354. Epub 2022 Mar 14.
Abstract
Our current view of how DNA-based genomes are efficiently and accurately replicated continues to evolve as new details emerge on the presence of ribonucleotides in DNA. Ribonucleotides are incorporated during eukaryotic DNA replication at rates that make them the most common noncanonical nucleotide placed into the nuclear genome, they are efficiently repaired, and their removal impacts genome integrity. This review focuses on three aspects of this subject: the incorporation of ribonucleotides into the eukaryotic nuclear genome during replication by B-family DNA replicases, how these ribonucleotides are removed, and the consequences of their presence or removal for genome stability and disease.
摘要
我们对基于 DNA 的基因组如何高效准确复制的现有认识随着核糖核苷酸在 DNA 中存在的新细节不断发展而不断演变。在真核生物 DNA 复制过程中，核糖核苷酸被掺入的速度使其成为被掺入核基因组的最常见的非 canonical 核苷酸，它们能被有效修复，其去除会影响基因组完整性。这篇综述集中讨论了该主题的三个方面：B 族 DNA 复制酶在复制过程中掺入真核核基因组中的核糖核苷酸、这些核糖核苷酸如何被去除，以及它们的存在或去除对基因组稳定性和疾病的影响。
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