Department of Structural and Chemical Biology, Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, Madrid, Spain; email:
Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA; email:
Annu Rev Biochem. 2022 Jun 21;91:321-351. doi: 10.1146/annurev-biochem-040320-104151. Epub 2022 Mar 14.
The cellular interior is composed of a variety of microenvironments defined by distinct local compositions and composition-dependent intermolecular interactions. We review the various types of nonspecific interactions between proteins and between proteins and other macromolecules and supramolecular structures that influence the state of association and functional properties of a given protein existing within a particular microenvironment at a particular point in time. The present state of knowledge is summarized, and suggestions for fruitful directions of research are offered.
细胞内部由多种微环境组成，这些微环境由不同的局部组成和组成依赖的分子间相互作用定义。我们回顾了蛋白质之间以及蛋白质与其他大分子和超分子结构之间各种类型的非特异性相互作用，这些相互作用影响特定微环境中特定时间点特定蛋白质的缔合状态和功能特性。总结了目前的知识状况，并提出了有希望的研究方向的建议。
