• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

遗传元件P4质粒状态的调控

Regulation of the plasmid state of the genetic element P4.

作者信息

Alano P, Dehò G, Sironi G, Zangrossi S

出版信息

Mol Gen Genet. 1986 Jun;203(3):445-50. doi: 10.1007/BF00422069.

DOI:10.1007/BF00422069
PMID:3528749
Abstract

After infection of sensitive cells in the absence of a helper phage, the satellite bacteriophage P4 enters a temporary phase of uncommitted replication followed by commitment to either the repressed-integrated condition or the derepressed-high copy number mode of replication. The transient phase and the stable plasmid condition differ from each other in the pattern of protein synthesis, in the rate of P4 DNA replication and in the expression of some gene functions. The regulatory condition characteristic of the P4 plasmid state affects a superinfecting genome, preventing the establishment of the P4 immune condition.

摘要

在没有辅助噬菌体的情况下感染敏感细胞后,卫星噬菌体P4进入一个未确定复制的临时阶段,随后进入被抑制的整合状态或去抑制的高拷贝数复制模式。短暂阶段和稳定的质粒状态在蛋白质合成模式、P4 DNA复制速率以及一些基因功能的表达方面彼此不同。P4质粒状态的调节条件会影响超级感染的基因组,阻止P4免疫条件的建立。

相似文献

1
Regulation of the plasmid state of the genetic element P4.遗传元件P4质粒状态的调控
Mol Gen Genet. 1986 Jun;203(3):445-50. doi: 10.1007/BF00422069.
2
Propagation of satellite phage P4 as a plasmid.卫星噬菌体P4作为质粒的增殖
Proc Natl Acad Sci U S A. 1982 Jan;79(2):515-9. doi: 10.1073/pnas.79.2.515.
3
Plasmid mode of propagation of the genetic element P4.遗传元件P4的质粒传播模式。
J Mol Biol. 1984 Sep 15;178(2):191-207. doi: 10.1016/0022-2836(84)90139-6.
4
The plasmid status of satellite bacteriophage P4.卫星噬菌体P4的质粒状态
Plasmid. 2001 Jan;45(1):1-17. doi: 10.1006/plas.2000.1497.
5
Phasmid P4: manipulation of plasmid copy number and induction from the integrated state.杆状噬菌体P4:质粒拷贝数的调控及从整合状态的诱导
J Bacteriol. 1984 Apr;158(1):208-15. doi: 10.1128/jb.158.1.208-215.1984.
6
Alternative promoters in the development of bacteriophage plasmid P4.噬菌体质粒P4发育过程中的替代启动子
J Virol. 1988 May;62(5):1697-704. doi: 10.1128/JVI.62.5.1697-1704.1988.
7
Bacteriophage P2 ogr and P4 delta genes act independently and are essential for P4 multiplication.噬菌体P2 ogr和P4 delta基因独立发挥作用,对P4的增殖至关重要。
J Bacteriol. 1990 Jul;172(7):3549-58. doi: 10.1128/jb.172.7.3549-3558.1990.
8
Construction of a novel plasmid-phage hybrid: use of the hybrid to demonstrate ColE1 DNA replication in vivo in the absence of a ColE1-specified protein.新型质粒-噬菌体杂种的构建:利用该杂种在无ColE1特异性蛋白的情况下体内证明ColE1 DNA复制。
Proc Natl Acad Sci U S A. 1978 May;75(5):2200-4. doi: 10.1073/pnas.75.5.2200.
9
A new gene of bacteriophage P4 that controls DNA replication.一种控制DNA复制的噬菌体P4新基因。
J Bacteriol. 1994 Oct;176(19):6059-65. doi: 10.1128/jb.176.19.6059-6065.1994.
10
Bacteriophage P4 DNA replication. Location of the P4 origin.噬菌体P4 DNA复制。P4 复制起点的定位。
J Mol Biol. 1985 Apr 20;182(4):519-27. doi: 10.1016/0022-2836(85)90238-4.

引用本文的文献

1
Translation of two nested genes in bacteriophage P4 controls immunity-specific transcription termination.噬菌体P4中两个嵌套基因的翻译控制免疫特异性转录终止。
J Bacteriol. 1999 Sep;181(17):5225-33. doi: 10.1128/JB.181.17.5225-5233.1999.
2
Derepression of prophage P2 by satellite phage P4: cloning of the P4 epsilon gene and identification of its product.卫星噬菌体P4对原噬菌体P2的去阻遏作用:P4 ε基因的克隆及其产物的鉴定。
J Virol. 1997 Jun;71(6):4502-8. doi: 10.1128/JVI.71.6.4502-4508.1997.
3
Cnr protein, the negative regulator of bacteriophage P4 replication, stimulates specific DNA binding of its initiator protein alpha.

本文引用的文献

1
ISOLATION AND CHARACTERIZATION OF RECOMBINATION-DEFICIENT MUTANTS OF ESCHERICHIA COLI K12.大肠杆菌K12重组缺陷突变体的分离与鉴定
Proc Natl Acad Sci U S A. 1965 Feb;53(2):451-9. doi: 10.1073/pnas.53.2.451.
2
Mutants of satellite virus P4 that cannot derepress their bacteriophage P2 helper.无法解除对其噬菌体P2辅助病毒抑制作用的卫星病毒P4突变体。
J Mol Biol. 1981 May 5;148(1):1-19. doi: 10.1016/0022-2836(81)90232-1.
3
Propagation of satellite phage P4 as a plasmid.卫星噬菌体P4作为质粒的增殖
Cnr蛋白是噬菌体P4复制的负调控因子,可刺激其起始蛋白α与特定DNA的结合。
J Bacteriol. 1997 May;179(9):2817-22. doi: 10.1128/jb.179.9.2817-2822.1997.
4
Polynucleotide phosphorylase of Escherichia coli is required for the establishment of bacteriophage P4 immunity.大肠杆菌的多核苷酸磷酸化酶是噬菌体P4免疫建立所必需的。
J Bacteriol. 1996 Sep;178(18):5513-21. doi: 10.1128/jb.178.18.5513-5521.1996.
5
Mechanisms of genome propagation and helper exploitation by satellite phage P4.卫星噬菌体P4的基因组传播和辅助利用机制
Microbiol Rev. 1993 Sep;57(3):683-702. doi: 10.1128/mr.57.3.683-702.1993.
6
A new gene of bacteriophage P4 that controls DNA replication.一种控制DNA复制的噬菌体P4新基因。
J Bacteriol. 1994 Oct;176(19):6059-65. doi: 10.1128/jb.176.19.6059-6065.1994.
7
Control of transcription termination by an RNA factor in bacteriophage P4 immunity: identification of the target sites.噬菌体P4免疫中RNA因子对转录终止的控制:靶位点的鉴定
J Bacteriol. 1995 Mar;177(6):1425-34. doi: 10.1128/jb.177.6.1425-1434.1995.
8
Alternative promoters in the development of bacteriophage plasmid P4.噬菌体质粒P4发育过程中的替代启动子
J Virol. 1988 May;62(5):1697-704. doi: 10.1128/JVI.62.5.1697-1704.1988.
9
Activation of prophage P4 by the P2 Cox protein and the sites of action of the Cox protein on the two phage genomes.P2 Cox蛋白对原噬菌体P4的激活作用以及Cox蛋白在两个噬菌体基因组上的作用位点。
Proc Natl Acad Sci U S A. 1989 Jun;86(11):3973-7. doi: 10.1073/pnas.86.11.3973.
10
Nonessential region of bacteriophage P4: DNA sequence, transcription, gene products, and functions.噬菌体P4的非必需区域:DNA序列、转录、基因产物及功能
J Virol. 1990 Jan;64(1):24-36. doi: 10.1128/JVI.64.1.24-36.1990.
Proc Natl Acad Sci U S A. 1982 Jan;79(2):515-9. doi: 10.1073/pnas.79.2.515.
4
Lysogenization by satellite phage P4.卫星噬菌体P4的溶原化作用。
Virology. 1981 Aug;113(1):20-38. doi: 10.1016/0042-6822(81)90133-1.
5
Genetic analysis of bacteriophage P4 using P4-plasmid ColE1 hybrids.使用P4-质粒ColE1杂种对噬菌体P4进行遗传分析。
Mol Gen Genet. 1980 Feb;177(3):399-412. doi: 10.1007/BF00271478.
6
The bacteriophage P4 alpha gene is the structural gene for bacteriophage P4-induced RNA polymerase.噬菌体P4的α基因是噬菌体P4诱导的RNA聚合酶的结构基因。
J Virol. 1983 Oct;48(1):157-69. doi: 10.1128/JVI.48.1.157-169.1983.
7
Circular genetic map of satellite bacteriophage P4.卫星噬菌体P4的环状遗传图谱。
Virology. 1983 Apr 15;126(1):267-78. doi: 10.1016/0042-6822(83)90478-6.
8
Plasmid mode of propagation of the genetic element P4.遗传元件P4的质粒传播模式。
J Mol Biol. 1984 Sep 15;178(2):191-207. doi: 10.1016/0022-2836(84)90139-6.
9
Phasmid P4: manipulation of plasmid copy number and induction from the integrated state.杆状噬菌体P4:质粒拷贝数的调控及从整合状态的诱导
J Bacteriol. 1984 Apr;158(1):208-15. doi: 10.1128/jb.158.1.208-215.1984.
10
An Escherichia coli gene required for bacteriophage P2-lambda interference.噬菌体P2-λ干扰所需的大肠杆菌基因。
J Virol. 1983 Dec;48(3):616-26. doi: 10.1128/JVI.48.3.616-626.1983.