Flatiron Health, New York, NY, USA.
Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
J Matern Fetal Neonatal Med. 2022 Dec;35(25):9631-9638. doi: 10.1080/14767058.2022.2049751. Epub 2022 Mar 14.
Education is considered one of the most robust determinants of health. However, it is unclear whether maternal education and paternal education have differential impacts on perinatal health outcomes. We assess maternal and paternal education differences and their association with adverse birth outcomes in a large birth cohort from Ontario, Canada.
The OaK Birth Cohort recruited patients from Ontario, Canada, between October 2002 and April 2009. We recruited mothers were recruited between 12 and 20 weeks' gestation and collected both mother and infant data. The final sample size of the cohort was 8,085 participants. We use logistic regression to model the probability of preterm birth (less than 34 and 37 weeks' gestation), small-for-gestational-age (SGA), or stillbirth as a function of maternal and paternal educational attainment. We adjust for household-level income, maternal and paternal race and ethnicity, and compare the strength of the association between maternal and paternal education on outcomes using Wald tests.
7,928 mother-father-offspring triads were available for the current analysis. 75% of mothers and fathers had college or university level education, and 8.7% of mothers experienced preterm delivery. Compared to mothers with college or university education, mothers with a high school education had an odds ratio of 1.37 (95% CI: 1.01-1.87) for SGA. Paternal education was not associated with infant outcomes. Comparing the odds ratios for maternal education and paternal education showed a stronger association than paternal education at the high school level for SGA birth (difference in odds ratio: 1.95, 95% CI: 1.13-3.36, = .016) among women at least 25 years old.
Maternal education was associated with SGA, and this effect was more robust than paternal education, but both associations were weaker than previously reported.
教育被认为是健康的最有力决定因素之一。然而,目前尚不清楚母亲的教育和父亲的教育对围产期健康结果有何不同影响。我们评估了安大略省加拿大一个大型出生队列中母亲和父亲教育的差异及其与不良出生结局的关联。
OaK 出生队列于 2002 年 10 月至 2009 年 4 月期间在加拿大安大略省招募患者。我们招募了妊娠 12 至 20 周的母亲,并收集了母亲和婴儿的数据。该队列的最终样本量为 8085 名参与者。我们使用逻辑回归模型来模拟早产(小于 34 周和 37 周)、小于胎龄儿(SGA)或死产的概率,作为母亲和父亲教育程度的函数。我们调整了家庭收入、母亲和父亲的种族和民族,并使用 Wald 检验比较了母亲和父亲教育对结果的关联强度。
当前分析中有 7928 个母亲-父亲-子女三胞胎。75%的母亲和父亲具有大学或大学学历,8.7%的母亲发生早产。与具有大学或大学学历的母亲相比,具有高中学历的母亲发生 SGA 的优势比为 1.37(95%CI:1.01-1.87)。父亲的教育与婴儿的结局无关。比较母亲教育和父亲教育的优势比表明,在至少 25 岁的女性中,与父亲的高中教育相比,父亲的高中教育与 SGA 出生的关联更强(优势比差异:1.95,95%CI:1.13-3.36,=0.016)。
母亲的教育与 SGA 有关,这种关联比父亲的教育更为显著,但这两种关联都比之前报道的要弱。