Department of Chemical Engineering and Materials Science, College of Convergence Engineering, Sangmyung University, Seoul 03016, Republic of Korea.
Department of Chemical Engineering and Materials Science, College of Convergence Engineering, Sangmyung University, Seoul 03016, Republic of Korea.
Carbohydr Polym. 2022 May 15;284:119184. doi: 10.1016/j.carbpol.2022.119184. Epub 2022 Jan 28.
The poly(3-hydroxybutyrate) (PHB) organogel monoliths were prepared by nonsolvent-induced phase separation (NIPS). The NIPS-derived organogels were solvent-exchanged with chitosan (CS) solution, resulting in the successful loading of CS into PHB hydrogel. With increasing the CS content, the as-prepared composite hydrogels became syringe injectable with excellent thixotropy due to the increase in the gel network's hydrophilicity. The hydrogels were successfully freeze-dried into PHB/CS composite aerogels, which exhibited remarkably improved compressive modulus/collapse strength of 1.6 MPa/159 kPa compared to 0.5 MPa/31 kPa for pure PHB aerogels. The effect of CS on gel crystallization and structure was also investigated. The amphiphilic PHB/CS hydrogels effectively entrapped both hydrophilic/cationic doxorubicin (DOX) and hydrophobic/anionic indomethacin (IDM). The drug release behavior depended on the charge interactions between drugs and CS. The accelerated DOX release in acidic condition from injected hydrogels owing to the charge repulsion shows potential for a controlled and localized cancer therapy.
聚（3-羟基丁酸酯）（PHB）有机凝胶块体通过非溶剂致相分离（NIPS）制备。NIPS 衍生的有机凝胶用壳聚糖（CS）溶液进行溶剂交换，从而成功地将 CS 负载到 PHB 水凝胶中。随着 CS 含量的增加，由于凝胶网络亲水性的增加，所制备的复合水凝胶具有出色的触变性，可通过注射器注射。水凝胶成功地冷冻干燥成 PHB/CS 复合气凝胶，与纯 PHB 气凝胶的 0.5 MPa/31 kPa 相比，其压缩模量/塌陷强度显著提高到 1.6 MPa/159 kPa。还研究了 CS 对凝胶结晶和结构的影响。两亲性 PHB/CS 水凝胶有效地包封了亲水性/阳离子阿霉素（DOX）和疏水性/阴离子吲哚美辛（IDM）。药物释放行为取决于药物与 CS 之间的电荷相互作用。由于电荷排斥，酸性条件下注射水凝胶中 DOX 的加速释放显示出用于控制和局部癌症治疗的潜力。
