Li Jiapeng, Wei Guotao, Yuan Yihao, Wang Ling, Qiu Miaohan, Li Bo, Ma Ruofei, Wu Jiawei, Shen Ziyi
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Science & Medicine, Northwest University, 229 North Taibai Road, Beilin District, Xi'an 710069, China.
College of Integrated Traditional Chinese and Western Medicine, Shaanxi University of Chinese Medicine, No.1 Century Avenue Middle Section, Xianyang 712046, China.
Pharmaceutics. 2025 Apr 17;17(4):529. doi: 10.3390/pharmaceutics17040529.
Antimicrobial delivery systems have undergone extensive development, yet conventional carriers still exhibit limitations such as low loading capacity, inadequate controlled release mechanisms, and cytotoxicity. Recent studies have increasingly demonstrated the potential of Hydrogel Microspheres (HMSs) for antimicrobial delivery. These microspheres exhibit small dimensions, high drug-loading capacity, and the ability to achieve deep-targeted delivery, complemented by adjustable physicochemical properties and biocompatibility that create favorable conditions for antimicrobial transportation. This review systematically examines HMS preparation strategies, characteristic properties, transported antimicrobials, and therapeutic applications. Particular emphasis is placed on critical preparation parameters governing HMS performance, especially those influencing drug delivery dynamics. We conclude by addressing current challenges and proposing actionable strategies for material optimization and clinical translation. This work aims to advance HMS-based antimicrobial delivery systems for more effective infection control.
抗菌递送系统已经历了广泛的发展，但传统载体仍存在诸如载药量低、控释机制不完善和细胞毒性等局限性。最近的研究越来越多地证明了水凝胶微球（HMSs）在抗菌递送方面的潜力。这些微球尺寸小、载药量大，并且能够实现深度靶向递送，同时具有可调节的物理化学性质和生物相容性，为抗菌剂运输创造了有利条件。本综述系统地研究了HMS的制备策略、特性、运输的抗菌剂以及治疗应用。特别强调了决定HMS性能的关键制备参数，尤其是那些影响药物递送动力学的参数。我们通过讨论当前的挑战并提出材料优化和临床转化的可行策略来得出结论。这项工作旨在推进基于HMS的抗菌递送系统，以实现更有效的感染控制。
