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UCH-L1 and GFAP Testing (i-STAT TBI Plasma) for the Detection of Intracranial Injury Following Mild Traumatic Brain Injury.

作者信息

Middleton Jennifer

机构信息

Ohio Health Riverside Methodist Hospital, Columbus, OH, USA.

出版信息

Am Fam Physician. 2022 Mar 1;105(3):313-314.

PMID:35289582
Abstract
摘要

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1
UCH-L1 and GFAP Testing (i-STAT TBI Plasma) for the Detection of Intracranial Injury Following Mild Traumatic Brain Injury.用于检测轻度创伤性脑损伤后颅内损伤的UCH-L1和GFAP检测（i-STAT TBI血浆检测）
Am Fam Physician. 2022 Mar 1;105(3):313-314.
2
The game changer: UCH-L1 and GFAP-based blood test as the first marketed in vitro diagnostic test for mild traumatic brain injury.变革者：UCH-L1 和 GFAP 为基础的血液检测成为首个上市的用于轻度创伤性脑损伤的体外诊断测试。
Expert Rev Mol Diagn. 2024 Jan-Feb;24(1-2):67-77. doi: 10.1080/14737159.2024.2306876. Epub 2024 Jan 31.
3
The Levels of Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 During the First Week After a Traumatic Brain Injury: Correlations With Clinical and Imaging Findings.创伤性脑损伤后第一周内胶质纤维酸性蛋白和泛素 C 末端水解酶-L1 的水平：与临床和影像学结果的相关性
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Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury.胶质纤维酸性蛋白和 UCH-L1 在伴有和不伴有轻度创伤性脑损伤的大型创伤患者中的时间过程和诊断准确性。
JAMA Neurol. 2016 May 1;73(5):551-60. doi: 10.1001/jamaneurol.2016.0039.
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Serum GFAP and UCH-L1 for prediction of absence of intracranial injuries on head CT (ALERT-TBI): a multicentre observational study.血清 GFAP 和 UCH-L1 对头 CT 未见颅内损伤的预测作用（ALERT-TBI）：一项多中心观察性研究。
Lancet Neurol. 2018 Sep;17(9):782-789. doi: 10.1016/S1474-4422(18)30231-X. Epub 2018 Jul 24.
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Can serum biomarkers be used to rule out significant intracranial pathology in emergency department patients with mild traumatic brain injury? A Systemic Review & Meta-Analysis.血清生物标志物能否用于排除急诊科轻度创伤性脑损伤患者的严重颅内病变？系统评价与荟萃分析。
Injury. 2022 Feb;53(2):259-271. doi: 10.1016/j.injury.2021.10.015. Epub 2021 Oct 30.
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Temporal response profiles of serum ubiquitin C-terminal hydrolase-L1 and the 145-kDa alpha II-spectrin breakdown product after severe traumatic brain injury in children.儿童严重创伤性脑损伤后血清泛素 C 末端水解酶-L1 和 145 kDa αII-血影蛋白降解产物的时间反应曲线
J Neurosurg Pediatr. 2018 Oct;22(4):369-374. doi: 10.3171/2018.4.PEDS17593. Epub 2018 Jun 29.
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Serum Concentrations of Ubiquitin C-Terminal Hydrolase-L1 and Glial Fibrillary Acidic Protein after Pediatric Traumatic Brain Injury.儿童创伤性脑损伤后血清泛素羧基末端水解酶-L1 和神经胶质纤维酸性蛋白浓度的变化
Sci Rep. 2016 Jun 20;6:28203. doi: 10.1038/srep28203.
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UCH-L1 is a Poor Serum Biomarker of Murine Traumatic Brain Injury After Polytrauma.UCH-L1 是一种较差的多创伤性脑损伤后小鼠创伤性脑损伤的血清生物标志物。
J Surg Res. 2019 Dec;244:63-68. doi: 10.1016/j.jss.2019.06.023. Epub 2019 Jul 3.
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Utility of Serum Biomarkers in the Diagnosis and Stratification of Mild Traumatic Brain Injury.血清生物标志物在轻度创伤性脑损伤诊断和分层中的应用
Acad Emerg Med. 2017 Jun;24(6):710-720. doi: 10.1111/acem.13174. Epub 2017 May 18.

引用本文的文献

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The relevance of combined testing of cerebrospinal fluid glial fibrillary acidic protein and ubiquitin C-terminal hydrolase L1 in multiple sclerosis and peripheral neuropathy.脑脊液胶质纤维酸性蛋白和泛素 C 末端水解酶 L1 联合检测在多发性硬化症和周围神经病变中的相关性
Neurol Sci. 2025 Mar;46(3):1301-1312. doi: 10.1007/s10072-024-07790-4. Epub 2024 Nov 20.
2
Characteristic of clinical trials related to traumatic brain injury registered on ClinicalTrials.gov over the past two decades (2004-2023).过去二十年（2004 - 2023年）在ClinicalTrials.gov上注册的与创伤性脑损伤相关的临床试验特征。
Front Med (Lausanne). 2024 Sep 16;11:1435762. doi: 10.3389/fmed.2024.1435762. eCollection 2024.
3
Early GFAP and UCH-L1 point-of-care biomarker measurements for the prediction of traumatic brain injury and progression in patients with polytrauma and hemorrhagic shock.
早期胶质纤维酸性蛋白（GFAP）和泛素羧基末端水解酶L1（UCH-L1）即时检测生物标志物测量用于预测多发伤和失血性休克患者的创伤性脑损伤及病情进展。
J Neurosurg. 2024 May 10:1-10. doi: 10.3171/2024.1.JNS232569.
4
The National Football League and traumatic brain injury: blood-based evaluation at the game.美国国家橄榄球联盟与创伤性脑损伤：比赛中的血液评估
Concussion. 2023 Sep 13;8(4):CNC111. doi: 10.2217/cnc-2023-0011. eCollection 2023 Aug.
5
Modulation of Inflammatory Response by Electromagnetic Field Stimulation in Traumatic Brain Injury in Yucatan Swine.尤卡坦猪创伤性脑损伤中电磁场刺激对炎症反应的调节作用
J Surg Res (Houst). 2024;7(1):20-40. doi: 10.26502/jsr.10020338. Epub 2024 Jan 31.
6
Study protocol for investigating the clinical performance of an automated blood test for glial fibrillary acidic protein and ubiquitin carboxy-terminal hydrolase L1 blood concentrations in elderly patients with mild traumatic BRAIN Injury and reference values (BRAINI-2 Elderly European study): a prospective multicentre observational study.研究方案：调查一种自动化血液检测方法在老年轻度创伤性脑损伤（mild traumatic brain injury，mTBI）患者中用于检测神经胶质纤维酸性蛋白和泛素羧基末端水解酶 L1 血浓度的临床性能及参考值（BRAINI-2 老年欧洲研究）：一项前瞻性多中心观察性研究。
BMJ Open. 2023 Jul 17;13(7):e071467. doi: 10.1136/bmjopen-2022-071467.
7
Inflammation biomarkers IL‑6 and IL‑10 may improve the diagnostic and prognostic accuracy of currently authorized traumatic brain injury tools.炎症生物标志物白细胞介素-6（IL-6）和白细胞介素-10（IL-10）可能会提高当前获批的创伤性脑损伤诊断工具的诊断和预后准确性。
Exp Ther Med. 2023 Jun 12;26(2):364. doi: 10.3892/etm.2023.12063. eCollection 2023 Aug.
8
Serum Glial Fibrillary Acidic Protein in Detecting Intracranial Injuries Following Minor Head Trauma; a Systematic Review and Meta-Analysis.血清胶质纤维酸性蛋白在检测轻度头部创伤后颅内损伤中的应用；一项系统评价与Meta分析
Arch Acad Emerg Med. 2023 Jan 1;11(1):e9. doi: 10.22037/aaem.v11i1.1682. eCollection 2023.
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Inflammatory Biomarkers of Traumatic Brain Injury.创伤性脑损伤的炎症生物标志物
Pharmaceuticals (Basel). 2022 May 25;15(6):660. doi: 10.3390/ph15060660.