Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104, India.
Central Frozen Semen Production and Training Institute, Bengaluru, Karnataka, 560088, India.
Future Microbiol. 2022 Apr;17:465-481. doi: 10.2217/fmb-2021-0158. Epub 2022 Mar 15.
The emergence of as a potential threat in persistent infections can be attributed to the plethora of virulence factors expressed by it. This review discusses the various virulence factors that help this pathogen to establish an infection and regulatory systems controlling these virulence factors. Cell-associated virulence factors such as flagella, type IV pili and non-pilus adhesins have been reviewed. Extracellular virulence factors have also been explained. Quorum-sensing systems present in play a cardinal role in regulating the expression of virulence factors. The identification of novel virulence factors in hypervirulent strains indicate that the expression of virulence is dynamic and constantly evolving. An understanding of this is critical for the better clinical management of infections.
作为一种潜在的威胁，在持续性感染中出现，可以归因于它所表达的大量毒力因子。这篇综述讨论了帮助这种病原体建立感染的各种毒力因子，以及控制这些毒力因子的调节系统。已经综述了细胞相关的毒力因子，如鞭毛、IV 型菌毛和非菌毛黏附素。还解释了细胞外毒力因子。在 中存在的群体感应系统在调节毒力因子的表达中起着关键作用。在高毒力菌株中鉴定出新的毒力因子表明，毒力的表达是动态的，并且在不断进化。理解这一点对于更好地临床管理感染至关重要。
