Instituto do Cancer do Estado de Sao Paulo (ICESP), São Paulo, Brazil.
Instituto do Cancer do Estado de Sao Paulo (ICESP), São Paulo, Brazil.
Cancer Epidemiol. 2022 Jun;78:102139. doi: 10.1016/j.canep.2022.102139. Epub 2022 Mar 12.
A recent Brazilian populational database analysis showed a concerning increase in breast cancer mortality rates among patients under 40 years. We aimed to evaluate the trends in the proportion of new breast cancer cases and deaths occurring in patients younger than 40 years over the last decade in Brazil.
We evaluated all consecutive breast cancer patients treated from 2009 to 2020 in a Brazilian tertiary cancer center. The proportions of new cases and deaths in patients younger than 40 years was compared between two time periods (2015-2020 versus 2009-2014) using Chi-squared test. Linear regression was used to evaluate the trends in the proportion of new cases and deaths in young patients over the years.
From 2009 to 2020, a total of 12,569 breast cancer patients started treatment at our institution; 1441 were younger than 40 years. From 2009 to 2014, 9.9% (95% CI 9.2-10.7%) were patients younger than 40 years compared to 12.9% (95% CI 12.1-13.8%) from 2015 to 2020. Similarly, the proportion of deaths among breast cancer patients younger than 40 years increased during the period (2009-2014: 9.6%, 95% CI 7.8-11.6%; 2015-2020: 12.4%, 95% CI 10.9-14%). The linear regression model showed a trend for an increasing proportion of new breast cancer cases occurring in patients under 40 years (P = 0.005). Proportion increased from 7.9% (95% CI 6.2-9.8%) in 2009 to 21.8% (95% CI 19.1-24.8%) in 2020. The trend for the increase in the proportion of deaths in this young population was also observed in the linear regression model (P = 0.01).
The proportion of new breast cancer cases and deaths among patients younger than 40 years has increased in a public Brazilian cancer center over the past decade. These results raise the concern for the need to reconsider primary and secondary prevention strategies for young women.
最近巴西的一项人群数据库分析显示，40 岁以下乳腺癌患者的死亡率令人担忧。我们旨在评估过去十年巴西 40 岁以下新乳腺癌病例和死亡人数的比例趋势。
我们评估了一家巴西三级癌症中心 2009 年至 2020 年期间连续治疗的所有乳腺癌患者。使用卡方检验比较两个时间段（2015-2020 年与 2009-2014 年）新病例和 40 岁以下患者死亡的比例。使用线性回归评估年轻患者新病例和死亡人数的年度比例趋势。
2009 年至 2020 年，共有 12569 名乳腺癌患者在我院接受治疗，其中 1441 名患者年龄小于 40 岁。2009 年至 2014 年，年龄小于 40 岁的患者占 9.9%（95%CI 9.2-10.7%），而 2015 年至 2020 年为 12.9%（95%CI 12.1-13.8%）。同样，40 岁以下乳腺癌患者的死亡比例在此期间也有所增加（2009-2014 年：9.6%，95%CI 7.8-11.6%；2015-2020 年：12.4%，95%CI 10.9-14%）。线性回归模型显示，40 岁以下新乳腺癌病例比例呈上升趋势（P=0.005）。比例从 2009 年的 7.9%（95%CI 6.2-9.8%）增加到 2020 年的 21.8%（95%CI 19.1-24.8%）。线性回归模型也观察到这一年轻人群死亡比例增加的趋势（P=0.01）。
过去十年，巴西一家公立癌症中心 40 岁以下新乳腺癌病例和死亡人数的比例有所增加。这些结果引发了对年轻女性初级和二级预防策略的必要性的关注。
