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PTB 超高脉冲剂量率参考电子束特性。

Characterization of the PTB ultra-high pulse dose rate reference electron beam.

机构信息

Physikalisch-Technische Bundesanstalt (PTB), Braunschweig, Germany.

Główny Urząd Miar (GUM), Poland.

出版信息

Phys Med Biol. 2022 Apr 8;67(8). doi: 10.1088/1361-6560/ac5de8.

DOI:10.1088/1361-6560/ac5de8
PMID:35290962
Abstract

. This investigation aims to present the characterisation and optimisation of an ultra-high pulse dose rate (UHPDR) electron beam at the PTB facility in Germany. A Monte Carlo beam model has been developed for dosimetry study for future investigation in FLASH radiotherapy and will be presented.. The 20 MeV electron beams generated by the research linear accelerator has been characterised both in-beamline with profile monitors and magnet spectrometer, and in-water with a diamond detector prototype. The Monte Carlo model has been used to investigate six different setups to enable different dose per pulse (DPP) ranges and beam sizes in water. The properties of the electron radiation field in water have also been characterised in terms of beam size, quality specifierand flatness. The beam stability has also been studied.. The difference between the Monte-Carlo simulated and measuredwas smaller than 0.5 mm. The simulated beam sizes agreed with the measured ones within 2 mm. Two suitable setups have been identified for delivering reference UHPDR electron beams. The first one is characterised by a SSD of 70 cm, while in the second one an SSD of 90 cm is used in combination with a 2 mm aluminium scattering plates. The two set-ups are quick and simple to install and enable an expected overall DPP range from 0.13 Gy up to 6.7 Gy per pulse.. The electron beams generated by the PTB research accelerator have shown to be stable throughout the four-months length of this investigation. The Monte Carlo models have shown to be in good agreement for beam size and depth dose and within 1% for the beam flatness. The diamond detector prototype has shown to be a promising tool to be used for relative measurements in UHPDR electron beams.

摘要

. 本研究旨在展示德国 PTB 设施中超高脉冲剂量率(UHPDR)电子束的特性和优化。已经为未来在 FLASH 放射治疗中的研究开发了用于剂量学研究的蒙特卡罗束模型,并将进行介绍。由研究线性加速器产生的 20 MeV 电子束已经在束线上用轮廓监测器和磁谱仪进行了特性描述,并且在水中用金刚石探测器原型进行了特性描述。蒙特卡罗模型已被用于研究六种不同的设置,以实现水中不同的脉冲剂量(DPP)范围和束斑尺寸。还根据束斑尺寸、品质指示器和平坦度来描述水中电子辐射场的特性。还研究了束流稳定性。蒙特卡罗模拟和测量之间的差异小于 0.5 毫米。模拟束斑尺寸与测量值相差在 2 毫米以内。已经确定了两种合适的设置来提供参考 UHPDR 电子束。第一种设置的 SSD 为 70 厘米,而在第二种设置中,使用 90 厘米的 SSD 并结合 2 毫米的铝散射板。这两种设置易于快速安装,并能够实现预期的总 DPP 范围,从每脉冲 0.13Gy 到 6.7Gy。PTB 研究加速器产生的电子束在整个四个月的研究过程中表现出稳定。蒙特卡罗模型在束斑尺寸和深度剂量方面表现出良好的一致性,在束斑平坦度方面的一致性在 1%以内。金刚石探测器原型已被证明是用于 UHPDR 电子束相对测量的有前途的工具。

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