COVID-19大流行对加拿大儿童流感相关住院、重症监护入院及死亡率的影响：一项基于人群的研究。

The effect of the COVID-19 pandemic on influenza-related hospitalization, intensive care admission and mortality in children in Canada: A population-based study.

作者信息

Groves Helen E, Papenburg Jesse, Mehta Kayur, Bettinger Julie A, Sadarangani Manish, Halperin Scott A, Morris Shaun K

机构信息

Division of Infectious Diseases, The Hospital for Sick Children, Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.

出版信息

Lancet Reg Health Am. 2022 Mar;7:100132. doi: 10.1016/j.lana.2021.100132. Epub 2021 Dec 5.

DOI:10.1016/j.lana.2021.100132

PMID:35291567

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8913102/

Abstract

BACKGROUND

The COVID-19 pandemic resulted in unprecedented implementation of wide-ranging public health measures globally. During the pandemic, dramatic decreases in seasonal influenza virus detection have been reported worldwide. Information on the impact on paediatric influenza-related hospitalisations is limited. We describe influenza-related hospitalisation in children in Canada following the onset of the COVID-19 pandemic.

METHODS

Data on influenza-related hospitalisations, intensive care unit (ICU) admissions and in-hospital deaths in children across Canada were obtained from the Canadian Immunisation Monitoring Program, ACTive (IMPACT). This national active surveillance initiative comprises 90% of all tertiary care paediatric beds in Canada. The study period included eleven influenza seasons, from the 2010/2011 season until the 2020/2021 season inclusive. Time series modelling was used to compare the observed to predicted influenza-related hospitalisations following the COVID-19 pandemic.

RESULTS

Following the COVID-19 pandemic there was a significant decrease in paediatric influenza-related hospitalisations compared to predicted influenza-related hospitalisations for this time period ( < 0•0001). No paediatric influenza-related hospitalisations, ICU admission or deaths were reported for the 2020/2021 influenza season.

CONCLUSIONS

We show complete absence of paediatric influenza infection-related hospitalisation in a Canadian National Surveillance Network during the 2020/2021 influenza season. This significant decrease is likely related in large part to non-pharmacological public health interventions implemented during the COVID-19 pandemic, although the potential role of viral interference is unknown.

FUNDING

The Canadian Immunisation Monitoring Program, Active (IMPACT) influenza surveillance is a national surveillance initiative managed by the Canadian Paediatric Society and conducted by the IMPACT network of paediatric investigators on behalf of the Public Health Agency of Canada's Centre for Immunisation and Respiratory Infectious Diseases.

摘要

背景

新冠疫情导致全球前所未有的广泛公共卫生措施的实施。在疫情期间，全球报告季节性流感病毒检测率大幅下降。关于对儿童流感相关住院治疗影响的信息有限。我们描述了新冠疫情爆发后加拿大儿童流感相关住院情况。

方法

从加拿大免疫监测项目“主动监测（IMPACT）”中获取加拿大儿童流感相关住院、重症监护病房（ICU）收治情况及院内死亡数据。这项全国性主动监测计划涵盖了加拿大90%的三级护理儿科床位。研究期包括从2010/2011季节到2020/2021季节（含）的11个流感季节。采用时间序列模型比较新冠疫情后观察到的与预测的流感相关住院情况。