Xu Kedi, Peng Rui, Zou Yuanlin, Jiang Xiaoru, Sun Qiuyu, Song Chunhua
Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
Henan Key Laboratory of Tumor Epidemiology, Zhengzhou University, Zhengzhou, China.
Int J Food Sci Nutr. 2022 Aug;73(5):588-599. doi: 10.1080/09637486.2022.2048359. Epub 2022 Mar 15.
The purpose of this article was to assess the existing systematic reviews and meta-analyses for the association between vitamin C intake and multiple health outcomes. A total of 76 meta-analyses (51 papers) of randomised controlled trials and observational studies with 63 unique health outcomes were identified. Dose-response analysis showed that vitamin C intake was associated with reduced risk of all-cause mortality, cardiovascular disease (CVD), oesophageal cancer, gastric cancer, cervical cancer and lung cancer with an increment of 50-100 mg per day. Beneficial associations were also identified for respiratory, neurological, ophthalmologic, musculoskeletal, renal and dental outcomes. Harmful associations were found for breast cancer and kidney stones for vitamin C supplement intake. The benefits of vitamin C intake outweigh the disadvantages for a range of health outcomes. However, the recommendation of vitamin C supplements needs to be cautious. More prospective studies and well-designed randomised controlled trials (RCTs) are needed.
本文旨在评估关于维生素C摄入量与多种健康结局之间关联的现有系统评价和荟萃分析。共识别出76项针对随机对照试验和观察性研究的荟萃分析（51篇论文），涉及63种不同的健康结局。剂量反应分析表明，每天增加50 - 100毫克维生素C摄入量与全因死亡率、心血管疾病（CVD）、食管癌、胃癌、宫颈癌和肺癌风险降低相关。在呼吸、神经、眼科、肌肉骨骼、肾脏和牙科结局方面也发现了有益关联。对于维生素C补充剂摄入，发现与乳腺癌和肾结石存在有害关联。对于一系列健康结局，维生素C摄入的益处大于弊端。然而，维生素C补充剂的推荐需要谨慎。需要更多的前瞻性研究和精心设计的随机对照试验（RCT）。
