[创伤性异位骨化的研究进展]
[Research progress of traumatic heterotopic ossification].
作者信息
Cao Guorui, Pei Fuxing
机构信息
Department of Knee Injury, Luoyang Orthopedic-Traumatological Hospital of Henan Province (Henan Provincial Orthopedic Hospital), Luoyang Henan, 471000, P. R. China.
Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2022 Mar 15;36(3):386-394. doi: 10.7507/1002-1892.202110078.
OBJECTIVE
To review and evaluate the research progress of traumatic heterotopic ossification (HO).
METHODS
The domestic and foreign related research literature on traumatic HO was widely consulted, and its etiology, pathogenesis, pathological progress, diagnosis, prevention, and treatment were summarized.
RESULTS
Traumatic HO is often caused by severe trauma such as joint operation, explosion injury, nerve injury, and burn. At present, it is widely believed that the occurrence of traumatic HO is closely related to inflammation and hypoxia. Oral non-steroidal anti-inflammatory drugs and surgery are the main methods to prevent and treat traumatic HO.
CONCLUSION
Nowadays, the pathogenesis of traumatic HO is still unclear, the efficiency of relevant prevention and treatment measures is low, and there is a lack of specific treatment method. In the future, it is necessary to further study the pathogenesis of traumatic HO and find specific prevention and treatment targets.
目的
回顾和评估创伤性异位骨化（HO）的研究进展。
方法
广泛查阅国内外有关创伤性HO的相关研究文献，总结其病因、发病机制、病理进展、诊断、预防及治疗。
结果
创伤性HO常由关节手术、爆炸伤、神经损伤和烧伤等严重创伤引起。目前，普遍认为创伤性HO的发生与炎症和缺氧密切相关。口服非甾体类抗炎药和手术是预防和治疗创伤性HO的主要方法。
结论
目前，创伤性HO的发病机制仍不明确，相关防治措施的疗效较低，且缺乏特异性治疗方法。未来，有必要进一步研究创伤性HO的发病机制，寻找特异性防治靶点。
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