Department of Epidemiology, Rollins School of Public Heath, Emory University, Atlanta, GA, United States of America.
Clinical and Translational Neuroscience Unit, Department of Neurology and Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, United States of America.
PLoS One. 2022 Mar 16;17(3):e0265498. doi: 10.1371/journal.pone.0265498. eCollection 2022.
The prevalence, incidence and risk factors of atrial fibrillation (AF) in a large, geographically and ethnically diverse cohort in the United States have not been fully described.
We analyzed data from 173,099 participants of the All of Us Research Program recruited in the period 2017-2019, with 92,318 of them having electronic health records (EHR) data available, and 35,483 having completed a medical history survey. Presence of AF at baseline was identified from self-report and EHR records. Incident AF was obtained from EHR. Demographic, anthropometric and clinical risk factors were obtained from questionnaires, baseline physical measurements and EHR.
At enrollment, mean age was 52 years old (range 18-89). Females and males accounted for 61% and 39% respectively. Non-Hispanic Whites accounted for 67% of participants, with non-Hispanic Blacks, non-Hispanic Asians and Hispanics accounting for 26%, 4% and 3% of participants, respectively. Among 92,318 participants with available EHR data, 3,885 (4.2%) had AF at the time of study enrollment, while the corresponding figure among 35,483 with medical history data was 2,084 (5.9%). During a median follow-up of 16 months, 354 new cases of AF were identified among 88,433 eligible participants. Individuals who were older, male, non-Hispanic white, had higher body mass index, or a prior history of heart failure or coronary heart disease had higher prevalence and incidence of AF.
The epidemiology of AF in the All of Us Research Program is similar to that reported in smaller studies with careful phenotyping, highlighting the value of this new resource for the study of AF and, potentially, other cardiovascular diseases.
在美国，一项大型、地域和种族多样化的队列研究中，尚未充分描述房颤（AF）的患病率、发病率和危险因素。
我们分析了 2017-2019 年期间参加“所有人研究计划”的 173099 名参与者的数据，其中 92318 人有电子健康记录（EHR）数据可用，35483 人完成了病史调查。基线时通过自我报告和 EHR 记录来确定 AF 的存在。通过 EHR 获得新发 AF。从问卷调查、基线身体测量和 EHR 中获得人口统计学、人体测量学和临床危险因素。
入组时平均年龄为 52 岁（范围 18-89 岁）。女性和男性分别占 61%和 39%。非西班牙裔白人占参与者的 67%，非西班牙裔黑人、非西班牙裔亚洲人和西班牙裔分别占参与者的 26%、4%和 3%。在 92318 名有可用 EHR 数据的参与者中，3885 名（4.2%）在研究入组时患有 AF，而在 35483 名有病史数据的参与者中，这一数字为 2084 名（5.9%）。在中位随访 16 个月期间，在 88433 名符合条件的参与者中，有 354 例新发生的 AF。年龄较大、男性、非西班牙裔白人、体重指数较高或有心力衰竭或冠心病既往史的个体，AF 的患病率和发病率较高。
“所有人研究计划”中 AF 的流行病学与经过仔细表型分析的较小研究报告的结果相似，这突出了这一新资源在 AF 及潜在其他心血管疾病研究中的价值。
