Comba Atakan, Atan Doğan
Department of Pediatrics, Faculty of Medicine, Hitit University, Çorum, Turkey.
Department of Otolaryngology, Faculty of Medicine, Hitit University, Çorum, Turkey.
Int J Pediatr Otorhinolaryngol. 2020 Jun;133:109936. doi: 10.1016/j.ijporl.2020.109936. Epub 2020 Feb 8.
Celiac disease is an autoimmune disorder that develops because of sensitivity to gluten-containing grains in genetically disposed individuals. Nasal mucociliary clearance is the most important protective factor that protects the upper and lower airways from foreign particulates. This study aimed to investigate the effect of celiac disease on nasal mucociliary clearance.
The study included patients with celiac disease and healthy children. Nasal mucociliary clearance time was measured using the saccharin test. The children's saccharin taste time was recorded in seconds.
Overall, 65 children were included: 43 patients with celiac disease (66.2%) and 22 healthy children (33.8%). Of all the children, 42 (64.6%) were female, and the average age was 11.8 ± 4 years. Nasal mucociliary clearance time of patients with celiac disease (531 ± 155 s) was significantly prolonged in comparison to that of healthy children (448 ± 80 s) (p = 0.006). No relationships were found between the diagnosis age, celiac type, and histopathological phase and compliance with the gluten-free diet and nasal mucociliary clearance time of patients with celiac disease.
This study showed that nasal mucociliary clearance was prolonged in patients with celiac disease. A defect in nasal mucociliary clearance increases the risk of infection and inflammation in small airways. Studies reported a high prevalence of respiratory tract infection in patients with celiac disease, which was associated with malnutrition, vitamin deficiency, and hyposplenism. The findings of the present study indicated that impairment of nasal mucociliary clearance could play a role in the development of frequent lung infections in patients with celiac disease.
乳糜泻是一种自身免疫性疾病，在具有遗传易感性的个体中，由于对含麸质谷物敏感而发病。鼻黏液纤毛清除功能是保护上、下呼吸道免受外来颗粒侵害的最重要保护因素。本研究旨在探讨乳糜泻对鼻黏液纤毛清除功能的影响。
本研究纳入了乳糜泻患者和健康儿童。采用糖精试验测量鼻黏液纤毛清除时间。记录儿童品尝糖精的时间（以秒为单位）。
总共纳入65名儿童：43名乳糜泻患者（66.2%）和22名健康儿童（33.8%）。所有儿童中，42名（64.6%）为女性，平均年龄为11.8±4岁。与健康儿童（448±80秒）相比，乳糜泻患者的鼻黏液纤毛清除时间（531±155秒）显著延长（p=0.006）。未发现乳糜泻患者的诊断年龄、乳糜泻类型、组织病理学分期以及无麸质饮食依从性与鼻黏液纤毛清除时间之间存在关联。
本研究表明，乳糜泻患者的鼻黏液纤毛清除功能延长。鼻黏液纤毛清除功能缺陷会增加小气道感染和炎症的风险。研究报告称，乳糜泻患者呼吸道感染的患病率较高，这与营养不良、维生素缺乏和脾功能减退有关。本研究结果表明，鼻黏液纤毛清除功能受损可能在乳糜泻患者频繁发生肺部感染的过程中起作用。
