Pintor Inês Almeida, Pereira Flávio, Cavadas Susana, Lopes Pedro
Department of Internal Medicine, Aveiro Hospital Center, Portugal.
Int J Mycobacteriol. 2022 Jan-Mar;11(1):113-115. doi: 10.4103/ijmy.ijmy_2_22.
Pott's disease is a vertebral infection caused by Mycobacterium tuberculosis. Indolent nature and subacute course are associated with late diagnosis. A clinical case is presented whose diagnosis was delayed by atypical presentation with progressive worsening of symptoms. Magnetic resonance imaging (MRI) of the dorsolumbar spine revealed T7-T8 angulation suggestive of secondary injury, with intracanalar extension and spinal cord compression. Gastric aspirate cultures, direct microscopy, and polymerase chain reaction (PCR) were A 79-yearold female came to the emergency department with right back pain, pleuritic, with 12 h of evolution. Anorexia and weight loss,1 month evolution. Computed tomography (CT) of the dorsal spine revealed T7-T8 lytic lesions, suggestive of secondary nature. Objectively:weight loss and pain during thoracic palpation. Annalistically: normocytic/normochromic anemia, hypercalcemia, hepatic cholestasis, C-reactive protein (CRP) 7.12 mg/dL. Chest X-ray and electrocardiogram without alterations. She was admitted in Internal Medicine service. Analytically: hypophosphatemia, parathyroid hormone elevated, CRP 6 mg/dL, Beta-2 microglobulin elevated, dyslipidemia, iron and folicacid deficiency.negative for M. tuberculosis. T8 aspiration CT guided: cultures/direct microscopy negative, PCR positive for M. tuberculosis. Introductionof antitubercular drugs. Worsening of symptomatology, with paraparesia. MRI of the dorsal spine revealed spondylodiscitis and spinal cordcompression in T7-T8. Diagnosis revealed vertebral tuberculosis with spinal cord compression. She was transferred to neurosurgery servicefor surgical treatment. There was clinical and analytical improvement. Draws attention to difficulty in diagnose a treatable disease in a patientwith a rare presentation.
波特氏病是一种由结核分枝杆菌引起的脊柱感染。其隐匿性和亚急性病程与诊断延迟有关。本文介绍了一例临床病例,该病例因非典型表现且症状逐渐加重而导致诊断延迟。胸腰椎磁共振成像(MRI)显示T7 - T8成角,提示继发性损伤,伴有椎管内扩展和脊髓受压。胃抽吸物培养、直接显微镜检查和聚合酶链反应(PCR)结果均为阴性。一名79岁女性因右背部疼痛伴胸膜炎前来急诊科,病程12小时。厌食和体重减轻,病程1个月。胸椎计算机断层扫描(CT)显示T7 - T8溶骨性病变,提示继发性病变。客观检查:体重减轻,胸部触诊时有疼痛。实验室检查:正细胞/正色素性贫血、高钙血症、肝内胆汁淤积、C反应蛋白(CRP)7.12mg/dL。胸部X线和心电图无异常。她被收入内科。分析检查:低磷血症、甲状旁腺激素升高、CRP 6mg/dL、β2微球蛋白升高、血脂异常、铁和叶酸缺乏。T8穿刺CT引导下:培养/直接显微镜检查阴性,结核分枝杆菌PCR阳性。开始使用抗结核药物。症状恶化,出现双下肢轻瘫。胸椎MRI显示T7 - T8椎体间盘炎和脊髓受压。诊断为椎体结核伴脊髓受压。她被转至神经外科进行手术治疗。临床和分析检查结果均有改善。该病例提醒人们注意诊断一名表现罕见的患者所患的可治疗疾病存在困难。