吲哚美辛对淋巴细胞增殖及迟发型超敏皮肤反应的增强作用。
Enhancement of lymphocyte blastogenic and delayed hypersensitivity skin responses by indomethacin.
作者信息
Muscoplat C C, Rakich P M, Thoen C O, Johnson D W
出版信息
Infect Immun. 1978 Jun;20(3):627-31. doi: 10.1128/iai.20.3.627-631.1978.
Incubation of Mycobacterium bovis-sensitized bovine peripheral blood lymphocytes with concanavalin A or M. bovis purified protein derivative and indomethacin caused a consistent, statistically significant increase in [3H] thymidine uptake as compared to cultures without indomethacin. The kinetics of the response showed that indomethacin must be added to lymphocyte cultures within hours after mitogen or antigen addition for enhancement of [3H]thymidine uptake to occur. Lymphocyte blastogenic responses to purified protein derivative were enhanced in both normal and M. bovis-sensitized lymphocyte cultures. However, enhancement of sensitized lymphocyte responses was significantly (P less than 0.01) greater than that in normal animals. Additionally, indomethacin treatment of M. bovis-sensitized guinea pigs singnificantly augmented delayed skin reactions to tuberculin. Delayed hypersensitive skin reactions were only enhanced when indomethacin was administered simultaneously with tuberculin.
用刀豆球蛋白A或牛分枝杆菌纯化蛋白衍生物以及消炎痛培养牛分枝杆菌致敏的牛外周血淋巴细胞，与未加消炎痛的培养物相比，[3H]胸腺嘧啶核苷摄取量持续且有统计学意义地显著增加。反应动力学表明，必须在有丝分裂原或抗原加入后的数小时内将消炎痛加入淋巴细胞培养物中，才能增强[3H]胸腺嘧啶核苷摄取。在正常和牛分枝杆菌致敏的淋巴细胞培养物中，对纯化蛋白衍生物的淋巴细胞增殖反应均得到增强。然而，致敏淋巴细胞反应的增强在统计学上显著（P小于0.01）大于正常动物。此外，对牛分枝杆菌致敏的豚鼠进行消炎痛处理可显著增强对结核菌素的迟发性皮肤反应。只有在与结核菌素同时给予消炎痛时，迟发性超敏皮肤反应才会增强。
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