环磷酸腺苷对人淋巴细胞亚群上前列腺素E2的反应
Cyclic adenosine monophosphate response to prostaglandin E2 on subpopulations of human lymphocytes.
作者信息
Goodwin J S, Kaszubowski P A, Williams R C
出版信息
J Exp Med. 1979 Nov 1;150(5):1260-4. doi: 10.1084/jem.150.5.1260.
Abstract
Receptors for prostaglandin E2 or histamine were measured on subpopulations of human lymphocytes, using the cyclic AMP increase after exposure to prostaglandin or histamine as an indicator for the presence of receptors. The cyclic AMP response to prostaglandin E2 was similar in unfractionated lymphocytes and the T-enriched and T-depleted fractions. Within the T-enriched population, T cells bearing a receptor for the Fc portion of IgG (T gamma-cells) had a 27.4-fold rise in cyclic AMP after exposure to prostaglandin E2, whereas the remaining T cells (non-T gamma cells) had a fourfold increase. It would appear that prostaglandin receptors are concentrated on a small subfraction of T gamma cells, comprising approximately 15% of the T-cell population. The cyclic AMP response to histamine was less than twofold in all lymphocyte fractions.
摘要
利用暴露于前列腺素或组胺后细胞内环磷酸腺苷（cAMP）的增加作为受体存在的指标，对人淋巴细胞亚群上的前列腺素E2或组胺受体进行了检测。未分级的淋巴细胞以及富含T细胞和T细胞耗竭的组分对前列腺素E2的cAMP反应相似。在富含T细胞的群体中，携带IgG Fc部分受体的T细胞（Tγ细胞）在暴露于前列腺素E2后cAMP升高了27.4倍，而其余T细胞（非Tγ细胞）则增加了四倍。似乎前列腺素受体集中在一小部分Tγ细胞上，约占T细胞群体的15%。所有淋巴细胞组分对组胺的cAMP反应均小于两倍。
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