Division of Experimental Pathology, Faculty of Medicine, Tottori University, 86 Nishicho, Yonago, 683-8503, Japan.
Department of Surgery, Division of Gastrointestinal and Pediatric Surgery, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago, 683-8504, Japan.
BMC Cancer. 2022 Mar 16;22(1):280. doi: 10.1186/s12885-022-09339-0.
Gastric cancer (GC) is one of the most common malignancies, and the liver is the most common site of hematogenous metastasis of GC. AMIGO2 is a type I transmembrane protein that has been implicated in tumour cell adhesion in adenocarcinomas; however, its importance in GC remains undetermined.
We analyzed AMIGO2 expression by immunohistochemistry using the specific monoclonal antibody for human AMIGO2 in 128 patients who underwent GC surgery to evaluate its relationship between various metastatic and clinical outcomes in GC.
Immunohistochemistry revealed that AMIGO2 expression was an independent prognostic factor for overall survival, disease-specific survival, and liver metastasis in GC patients.
This study showed that AMIGO2 is induced in GC tissues and can mediate hepatic metastasis. Determining AMIGO2 expression in GC will help predict patient prognosis and the incidence of liver metastasis.
胃癌（GC）是最常见的恶性肿瘤之一，肝脏是 GC 血行转移最常见的部位。AMIGO2 是一种 I 型跨膜蛋白，已被证实与腺癌中的肿瘤细胞黏附有关；然而，其在 GC 中的重要性尚不确定。
我们使用针对人 AMIGO2 的特异性单克隆抗体通过免疫组织化学分析了 128 例接受 GC 手术的患者中的 AMIGO2 表达，以评估其与 GC 中各种转移和临床结局之间的关系。
免疫组织化学显示，AMIGO2 表达是 GC 患者总生存、疾病特异性生存和肝转移的独立预后因素。
本研究表明 AMIGO2 在 GC 组织中被诱导，并能介导肝转移。确定 GC 中的 AMIGO2 表达将有助于预测患者的预后和肝转移的发生。
