College of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
AAPS PharmSciTech. 2022 Mar 16;23(4):90. doi: 10.1208/s12249-022-02237-5.
Due to the high surface area, adjustable surface and pore structures, and excellent biocompatibility, nano- and micro-sized silica have certainly attracted the attention of many researchers in the medical fields. This review focuses on the multifunctional roles of silica in different pharmaceutical formulations including solid preparations, liquid drugs, and advanced drug delivery systems. For traditional solid preparations, it can improve compactibility and flowability, promote disintegration, adjust hygroscopicity, and prevent excessive adhesion. As for liquid drugs and preparations, like volatile oil, ethers, vitamins, and self-emulsifying drug delivery systems, silica with adjustable pore structures is a good adsorbent for solidification. Also, silica with various particle sizes, surface characteristics, pore structure, and surface modification controlled by different synthesis methods has gained wide attention owing to its unparalleled advantages for drug delivery and disease diagnosis. We also collate the latest pharmaceutical applications of silica sorted out by formulations. Finally, we point out the thorny issues for application and survey future trends pertaining to silica in an effort to provide a comprehensive overview of its future development in the medical fields. Graphical Abstract.
由于具有高比表面积、可调节的表面和孔结构以及出色的生物相容性，纳米和微米级二氧化硅无疑引起了医学领域众多研究人员的关注。本综述重点介绍了二氧化硅在不同药物制剂中的多功能作用，包括固体制剂、液体制剂和先进的药物传递系统。对于传统的固体制剂，它可以提高可压缩性和流动性，促进崩解，调节吸湿性，防止过度粘连。对于液体制剂和制剂，如挥发油、醚类、维生素和自乳化药物传递系统，具有可调节孔结构的二氧化硅是固化的良好吸附剂。此外，通过不同合成方法控制的具有各种粒径、表面特性、孔结构和表面改性的二氧化硅因其在药物传递和疾病诊断方面的无与伦比的优势而受到广泛关注。我们还整理了按制剂分类的最新药物应用。最后，我们指出了应用中的棘手问题，并调查了未来与二氧化硅相关的趋势，以期全面概述其在医学领域的未来发展。
