Kulasekera K B, Siriwardhana Chathura
Department of Bioinformatics & Biostatistics, University of Louisville, Louisville, KY 40202, USA.
Department of Quantitative Health Sciences, University of Hawaii John A. Burns School of Medicine, Honolulu, HI 96813, USA.
Commun Stat Simul Comput. 2022;51(2):554-569. doi: 10.1080/03610918.2019.1656739. Epub 2019 Sep 10.
In this work we propose a novel method for treatment selection based on individual covariate information when the treatment response is multivariate and data are available from a crossover design. Our method covers any number of treatments and it can be applied for a broad set of models. The proposed method uses a rank aggregation technique to estimate an ordering of treatments based on ranked lists of treatment performance measures such as smooth conditional means and conditional probability of a response for one treatment dominating others. An empirical study demonstrates the performance of the proposed method in finite samples.
在这项工作中,我们提出了一种新颖的方法,用于在治疗反应为多变量且数据来自交叉设计时,基于个体协变量信息进行治疗选择。我们的方法涵盖任意数量的治疗方法,并且可应用于广泛的模型集。所提出的方法使用秩聚合技术,根据治疗性能度量的排序列表(如平滑条件均值和一种治疗优于其他治疗的反应条件概率)来估计治疗的排序。一项实证研究证明了所提出方法在有限样本中的性能。