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基于多响应的个性化治疗选择,利用多种治疗交叉设计的数据

Multi-Response Based Personalized Treatment Selection with Data from Crossover Designs for Multiple Treatments.

作者信息

Kulasekera K B, Siriwardhana Chathura

机构信息

Department of Bioinformatics & Biostatistics, University of Louisville, Louisville, KY 40202, USA.

Department of Quantitative Health Sciences, University of Hawaii John A. Burns School of Medicine, Honolulu, HI 96813, USA.

出版信息

Commun Stat Simul Comput. 2022;51(2):554-569. doi: 10.1080/03610918.2019.1656739. Epub 2019 Sep 10.

Abstract

In this work we propose a novel method for treatment selection based on individual covariate information when the treatment response is multivariate and data are available from a crossover design. Our method covers any number of treatments and it can be applied for a broad set of models. The proposed method uses a rank aggregation technique to estimate an ordering of treatments based on ranked lists of treatment performance measures such as smooth conditional means and conditional probability of a response for one treatment dominating others. An empirical study demonstrates the performance of the proposed method in finite samples.

摘要

在这项工作中,我们提出了一种新颖的方法,用于在治疗反应为多变量且数据来自交叉设计时,基于个体协变量信息进行治疗选择。我们的方法涵盖任意数量的治疗方法,并且可应用于广泛的模型集。所提出的方法使用秩聚合技术,根据治疗性能度量的排序列表(如平滑条件均值和一种治疗优于其他治疗的反应条件概率)来估计治疗的排序。一项实证研究证明了所提出方法在有限样本中的性能。

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