光动力疗法中的四氮杂环辛烷-I和亚甲蓝-I
QuatCy-I and MHI-I in Photodynamic Therapy.
作者信息
Thavornpradit Sopida, Usama Syed Muhammad, Park G Kate, Dinh Jason, Choi Hak Soo, Burgess Kevin
机构信息
Department of Chemistry, Texas A&M University, Box 30012, College Station, Texas 77842, United States.
Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, United States.
出版信息
ACS Med Chem Lett. 2022 Feb 18;13(3):470-474. doi: 10.1021/acsmedchemlett.1c00640. eCollection 2022 Mar 10.
Abstract
MHI-I () and QuatCy-I () were compared in terms of properties important for early-stage photodynamic therapy preclinical candidates. Thus, experiments were performed to monitor dark cytotoxicities, light/dark cytotoxicity ratios, selectivity of localization in tumors over other organs, and clearance from the plasma.
摘要
就早期光动力疗法临床前候选药物的重要特性而言，对MHI-I（）和QuatCy-I（）进行了比较。因此，开展了实验以监测暗细胞毒性、光/暗细胞毒性比率、肿瘤相对于其他器官的定位选择性以及从血浆中的清除情况。
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