The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao Cancer Institute, Qingdao 266071, China; Institute of Biomedical Sciences, Nanchang University Medical College, Nanchang 330031, China.
The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao Cancer Institute, Qingdao 266071, China.
Trends Cell Biol. 2022 Sep;32(9):786-799. doi: 10.1016/j.tcb.2022.02.003. Epub 2022 Mar 14.
Gene transcription and cell metabolism are two fundamental biological processes that mutually regulate each other. Upregulated or altered expression of glucose metabolic genes in glycolysis and gluconeogenesis is a major driving force of enhanced aerobic glycolysis in tumor cells. Importantly, glycolytic and gluconeogenic enzymes in tumor cells acquire moonlighting functions and directly regulate gene expression by modulating chromatin or transcriptional complexes. The mutual regulation between cellular metabolism and gene expression in a feedback mechanism constitutes a unique feature of tumor cells and provides specific molecular and functional targets for cancer treatment.
基因转录和细胞代谢是两个相互调节的基本生物学过程。糖酵解和糖异生中葡萄糖代谢基因的上调或改变表达是肿瘤细胞中增强有氧糖酵解的主要驱动力。重要的是，肿瘤细胞中的糖酵解和糖异生酶获得了兼职功能，并通过调节染色质或转录复合物直接调节基因表达。细胞代谢和基因表达之间的相互调节在反馈机制中构成了肿瘤细胞的独特特征，并为癌症治疗提供了特定的分子和功能靶点。
