Department of Hepatobiliary Surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410005, P.R. China.
Mol Med Rep. 2022 May;25(5). doi: 10.3892/mmr.2022.12687. Epub 2022 Mar 18.
Intrahepatic cholangiocarcinoma (ICC) is a primary malignant liver tumour whose incidence is second only to that of hepatocellular carcinoma. ICC is a highly heterogeneous disease arising from neoplastic transformation of intrahepatic biliary epithelial cells (cholangiocytes), and it is characterized by a very poor prognosis. Signal transducer and activator of transcription 3 (STAT3) is an important oncogene that is widely expressed in numerous cancers. STAT3 is a candidate target for the treatment of ICC. However, studies on STAT3 and the occurrence and development of ICC require improvements. Therefore, the present review summarized the mechanism of STAT3 in ICC and provided a theoretical basis for STAT3 to become an effective target for determining the prognosis and treatment of ICC.
肝内胆管癌（ICC）是一种原发性恶性肝脏肿瘤，其发病率仅次于肝细胞癌。ICC 是一种高度异质性疾病，由肝内胆管上皮细胞（胆管细胞）的肿瘤转化引起，其预后非常差。信号转导子和转录激活子 3（STAT3）是一种广泛表达于多种癌症中的重要癌基因。STAT3 是 ICC 治疗的候选靶点。然而，STAT3 与 ICC 的发生和发展的相关研究尚需进一步完善。因此，本综述总结了 STAT3 在 ICC 中的作用机制，为 STAT3 成为有效预测 ICC 预后和治疗靶点提供了理论依据。
