Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences (BUMS), Birjand, Iran.
Department of Immunology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Phytother Res. 2022 Apr;36(4):1616-1632. doi: 10.1002/ptr.7417. Epub 2022 Mar 18.
Systemic autoimmune diseases like rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematosus represent various autoimmune conditions identified by immune system dysregulation. The activation of immune cells, auto-antigen outbreak, inflammation, and multi-organ impairment is observed in these disorders. The immune system is an essential complex network of cells and chemical mediators which defends the organism's integrity against foreign microorganisms, and its precise operation and stability are compulsory to avoid a wide range of medical complications. Curcumin is a phenolic ingredient extracted from turmeric and belongs to the Zingiberaceae, or ginger family. Curcumin has multiple functions, such as inhibiting inflammation, oxidative stress, tumor cell proliferation, cell death, and infection. Nevertheless, the immunomodulatory influence of curcumin on immunological reactions/processes remains mostly unknown. In the present narrative review, we sought to provide current information concerning the preclinical and clinical uses of curcumin in systemic autoimmune diseases.
系统性自身免疫性疾病，如类风湿关节炎、多发性硬化症和系统性红斑狼疮，代表了免疫系统失调所识别的各种自身免疫性疾病。这些疾病中观察到免疫细胞的激活、自身抗原爆发、炎症和多器官损伤。免疫系统是一个由细胞和化学介质组成的复杂网络，它保护机体的完整性免受外来微生物的侵害，其精确的运作和稳定性是避免多种医学并发症的必要条件。姜黄素是从姜黄中提取的一种酚类成分，属于姜科或姜科。姜黄素具有多种功能，如抑制炎症、氧化应激、肿瘤细胞增殖、细胞死亡和感染。然而，姜黄素对免疫反应/过程的免疫调节影响在很大程度上尚不清楚。在本综述中，我们试图提供关于姜黄素在系统性自身免疫性疾病中的临床前和临床应用的最新信息。
