She Rong, Xu Pu
Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Haikou, 570208, China.
BDJ Open. 2024 Oct 25;10(1):82. doi: 10.1038/s41405-024-00268-7.
Oral submucosal fibrosis is a potentially life-threatening oral disease that significantly impacts physiological functions such as speech and swallowing while also diminishing the quality of life for patients. Currently, the mainstream treatment for oral submucosal fibrosis in clinical practice involves invasive glucocorticoid drugs such as injection therapy. However, this method often leads to intraoperative pain, anxiety, fear, and poor medical experience due to associated side effects.
There is an urgent need to actively explore new drugs and relatively noninvasive approaches for the treatment of oral submucosal fibrosis in order to enhance patients' medical experience and compliance. This has become a focal point of attention in clinical research. After conducting an extensive literature search, it was discovered that curcumin, a natural polyphenolic compound, exhibits potent anti-tumor, anti-inflammatory, antioxidant, anti-metastatic and anti-angiogenic properties. Moreover, curcumin holds significant clinical potential in the prevention and treatment of various diseases such as oral submucosal fibrosis.
This review presents a comprehensive elaboration encompassing the action mechanisms, biological activity, potential applications, and clinical characteristics of curcumin in the management of oral submucosal fibrosis, aiming to provide diagnostic insights and novel therapeutic perspectives for its prevention and treatment.
口腔黏膜下纤维化是一种潜在威胁生命的口腔疾病，会严重影响言语和吞咽等生理功能，同时降低患者的生活质量。目前，临床实践中治疗口腔黏膜下纤维化的主流方法包括使用注射疗法等侵入性糖皮质激素药物。然而，由于相关副作用，这种方法常常导致术中疼痛、焦虑、恐惧以及较差的就医体验。
迫切需要积极探索治疗口腔黏膜下纤维化的新药和相对无创的方法，以提高患者的就医体验和依从性。这已成为临床研究的关注焦点。在进行广泛的文献检索后，发现姜黄素这种天然多酚化合物具有强大的抗肿瘤、抗炎、抗氧化、抗转移和抗血管生成特性。此外，姜黄素在预防和治疗口腔黏膜下纤维化等多种疾病方面具有显著的临床潜力。
本综述全面阐述了姜黄素在口腔黏膜下纤维化管理中的作用机制、生物活性、潜在应用和临床特征，旨在为其预防和治疗提供诊断见解和新的治疗视角。
