Willoughby D A, Sedgwick A D, Giroud J P, Al-Duaij A Y, de Brito F
Biomed Pharmacother. 1986;40(2):45-9.
This mini-review outlines the development and application of the air pouch model during the past five years. It shows the importance of using the appropriate aged pouch to establish long-lasting chronic inflammation following immune and non-immune stimuli. Subsequently, the effects of different inflammatory environments were studied on implanted cartilage. It has been found that the inflammation used to date did not lead to an appreciable increase in the rate of cartilage degradation. This is discussed with the implications for new trends in therapeutic research applied to rheumatology.
本综述概述了气袋模型在过去五年中的发展与应用。它展示了使用合适年龄的气袋在免疫和非免疫刺激后建立持久慢性炎症的重要性。随后，研究了不同炎症环境对植入软骨的影响。已发现迄今为止所使用的炎症并未导致软骨降解速率显著增加。本文结合这一发现对应用于风湿病学的治疗研究新趋势的影响进行了讨论。
