Zeng Li, Xiang Rong, Fu Chunyan, Qu Zhihao, Liu Changwei
Southwest Hunan Research Center of Engineering for Development and Utilization of Traditional Chinese Medicine, School of Pharmacy, Shaoyang University, Shaoyang, Hunan 422000, China; National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Collaborative Innovation Centre of Utilisation of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha, Hunan 410128, China.
The Library of Shaoyang University, Shaoyang, Hunan 422000, China.
Biomed Pharmacother. 2022 May;149:112831. doi: 10.1016/j.biopha.2022.112831. Epub 2022 Mar 15.
Chlorogenic acid (CGA) is a phenolic compound that is widely distributed in honeysuckle, Eucommia, fruits and vegetables. It has various biological functions, including cardiovascular, nerve, kidney, and liver protection, and it exerts a protective effect on human health, according to clinical research and basic research. The intestine and brain are two important organs that are closely related in the human body. The intestine is even called the "second brain" in humans. However, among the many reports in the literature, an article systematically reporting the regulatory effects and specific mechanisms of CGA on the intestines and brain has not been published. In this context, this review uses the regulatory role and mechanism of CGA in the intestine and brain as the starting point and comprehensively reviews CGA metabolism in the body and the regulatory role and mechanism of CGA in the intestine and brain described in recent years. Additionally, the review speculates on the potential biological actions of CGA in the gut-brain axis. This study provides a scientific theory for CGA research in the brain and intestines and promotes the transformation of basic research and the application of CGA in food nutrition and health care.
绿原酸（CGA）是一种酚类化合物，广泛分布于金银花、杜仲、水果和蔬菜中。根据临床研究和基础研究，它具有多种生物学功能，包括对心血管、神经、肾脏和肝脏的保护作用，对人体健康发挥着保护作用。肠道和大脑是人体中密切相关的两个重要器官。肠道在人体中甚至被称为“第二大脑”。然而，在众多文献报道中，尚未发表一篇系统报道CGA对肠道和大脑的调节作用及具体机制的文章。在此背景下，本综述以CGA在肠道和大脑中的调节作用及机制为切入点，全面综述了近年来CGA在体内的代谢情况以及CGA在肠道和大脑中的调节作用及机制。此外，本综述还推测了CGA在肠-脑轴中的潜在生物学作用。本研究为CGA在脑和肠道方面的研究提供了科学理论依据，促进了基础研究的转化以及CGA在食品营养与保健中的应用。
