State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, PR China.
State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, PR China.
J Colloid Interface Sci. 2022 Jul;617:578-584. doi: 10.1016/j.jcis.2022.01.188. Epub 2022 Mar 9.
The low toxicity and good photo active property endow bismuth based metal-organic frameworks (MOFs) potential candidates for efficient light-sensitive drug carrier. In this work, SU-101, composed of Bi and ellagic acid (EA), is found to display high ciprofloxacin (CIP) loading ratio (85.8%) and controlled CIP release under light illumination (the maximum CIP release ratio is 95.56%). Further investigations suggest that hydrogen bond between the CO group in EA and the -OH group in CIP is responsible for above behavior. Light irradiation decreases the electron density around the CO group in EA, which consequently leads to the broken of the hydrogen bond and therefore the release of CIP. Further investigations suggest that SU-101 is universal for other drugs, such as norfloxacin (NOR), amoxicillin (AMO), tetracycline (TET) and doxorubicinhydrochloride (DOX), since all of them can form hydrogen bond with SU-101. This work suggests that SU-101 holds great potential as efficient light-sensitive drug carrier, and the investigation of other Bi based MOFs as drug carrier is under investigation.
低毒性和好的光活性使铋基金属-有机骨架（MOFs）成为高效光敏药物载体的潜在候选物。在这项工作中，发现由铋和鞣花酸（EA）组成的 SU-101 具有高载药量（85.8%）和光照射下的 CIP 控释性能（最大 CIP 释放率为 95.56%）。进一步的研究表明，EA 中的 CO 基团和 CIP 中的-OH 基团之间的氢键是导致上述行为的原因。光照会降低 EA 中 CO 基团周围的电子密度，从而导致氢键断裂，进而释放 CIP。进一步的研究表明，SU-101 对其他药物（如诺氟沙星（NOR）、阿莫西林（AMO）、四环素（TET）和盐酸多柔比星（DOX））也具有通用性，因为它们都可以与 SU-101 形成氢键。这项工作表明，SU-101 作为高效光敏药物载体具有巨大的潜力，并且正在研究其他基于铋的 MOFs 作为药物载体的应用。
