Department of Materials and Environmental Chemistry, Stockholm University, Stockholm 106 91, Sweden.
Laboratorio de Fisicoquímica y Reactividad de Superficies (LaFReS), Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, 04510, Ciudad de México, Mexico.
J Am Chem Soc. 2020 Sep 30;142(39):16795-16804. doi: 10.1021/jacs.0c07525. Epub 2020 Sep 17.
The first bioinspired microporous metal-organic framework (MOF) synthesized using ellagic acid, a common natural antioxidant and polyphenol building unit, is presented. BiO(HO)(CHO)·HO (SU-101) was inspired by bismuth phenolate metallodrugs, and could be synthesized entirely from nonhazardous or edible reagents under ambient aqueous conditions, enabling simple scale-up. Reagent-grade and affordable dietary supplement-grade ellagic acid was sourced from tree bark and pomegranate hulls, respectively. Biocompatibility and colloidal stability were confirmed by in vitro assays. The material exhibits remarkable chemical stability for a bioinspired MOF (pH = 2-14, hydrothermal conditions, heated organic solvents, biological media, SO and HS), attributed to the strongly chelating phenolates. A total HS uptake of 15.95 mmol g was recorded, representing one of the highest HS capacities for a MOF, where polysulfides are formed inside the pores of the material. Phenolic phytochemicals remain largely unexplored as linkers for MOF synthesis, opening new avenues to design stable, eco-friendly, scalable, and low-cost MOFs for diverse applications, including drug delivery.
首次合成了一种基于鞣酸（一种常见的天然抗氧化剂和多酚建筑单元）的仿生微孔金属有机骨架（MOF）。BiO(HO)(CHO)·HO（SU-101）的灵感来自于双酚金属药物，并且可以在环境水条件下完全使用非危险或可食用的试剂合成，从而实现简单的放大。试剂级和负担得起的膳食补充剂级别的鞣酸分别来自树皮和石榴皮。通过体外试验证实了该材料具有良好的生物相容性和胶体稳定性。该材料具有出色的化学稳定性，适用于仿生 MOF（pH=2-14、水热条件、加热有机溶剂、生物介质、SO 和 HS），这归因于其强螯合的酚盐。记录到的总 HS 吸收量为 15.95mmol g，这是 MOF 中 HS 容量最高的之一，其中多硫化物在材料的孔内形成。酚类植物化学物质在作为 MOF 合成的连接体方面在很大程度上仍未得到探索，为设计稳定、环保、可扩展和低成本的 MOF 开辟了新途径，可应用于各种领域，包括药物输送。
