Department of Materials Engineering, College of Materials and Textile, Zhejiang Sci-Tech University, Hangzhou 310018, PR China.
Dalton Trans. 2018 Nov 13;47(44):15882-15887. doi: 10.1039/c8dt03202e.
A biocompatible metal-organic framework Zn-GA comprising zinc ions and the bio-friendly molecule l-glutamic acid (GA) is synthesized as a drug delivery system, and controlled drug release triggered by pH and thermal stimuli without premature delivery is realized. The anticancer drug methotrexate (MTX) is selected to be encapsulated into the crystal which possesses one-dimensional channels along the a axis. The on-command drug carrier shows superior biocompatibility, extremely low toxicity, satisfactory loading capabilities and excellent dual-responsiveness, indicating its practical application as an efficient drug carrier with controlled release.
一种由锌离子和生物友好分子 l-谷氨酸（GA）组成的生物相容性金属有机骨架 Zn-GA 被合成作为一种药物输送系统，并实现了 pH 和热刺激触发的药物控制释放，而不会发生过早释放。选择抗癌药物甲氨蝶呤（MTX）封装到晶体中，该晶体沿 a 轴具有一维通道。这种按需药物载体表现出优异的生物相容性、极低的毒性、令人满意的负载能力和优异的双重响应性，表明其作为具有控制释放的高效药物载体具有实际应用前景。
