Prineas R J, Gomez-Marin O, Sinaiko A R
Clin Exp Hypertens A. 1986;8(4-5):583-604. doi: 10.3109/10641968609046576.
Research into the relationship between dietary electrolytes and the primary cause and treatment of hypertension has now reached the stage where long-term, detailed, controlled, randomized, clinical trials of intervention need to be carried out among those at high risk, including children. Such trials must incorporate methods for estimating "sensitive" responders. The designs should also include precise measures of change in dietary electrolyte intake and allow for analysis of interaction of the effects of individual electrolytes. We have sketched the unforeseen errors, that now must be avoided, from earlier studies and given an outline of a current study that sets out to meet optimum requirements. It is to be hoped that many similar studies will soon be initiated in multiple population groups.
对饮食中电解质与高血压的主要病因及治疗之间关系的研究，目前已进入需要对包括儿童在内的高危人群开展长期、详细、对照、随机干预临床试验的阶段。此类试验必须纳入估算“敏感”反应者的方法。设计还应包括精确测量饮食中电解质摄入量的变化，并考虑对单个电解质效应的相互作用进行分析。我们总结了早期研究中现在必须避免的意外错误，并概述了一项旨在满足最佳要求的当前研究。希望很快能在多个人群组中开展许多类似研究。
