Department of Physiology, Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, Brno, Czech Republic.
Department of Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, Brno, Czech Republic.
J Comp Pathol. 2022 Apr;192:11-17. doi: 10.1016/j.jcpa.2022.01.003. Epub 2022 Feb 18.
Despite their high prevalence, the aetiopathogenesis of ovarian cysts in guinea pigs (Cavia porcellus) is unknown. We examined tissue samples of cystic ovaries from 20 guinea pigs by histopathology and immunohistochemistry for CD10 antigen, and determined the concentrations of Na, K, Cl, oestradiol and progesterone in the cyst fluid. Cystic rete ovarii were found in all 20 guinea pigs but no follicular cysts. Concentrations of Na (142.2 ± 5.04 mmol/l), K (5.6 ± 0.76 mmol/l) and Cl (116.1 ± 5.25 mmol/l) corresponded to extracellular, rather than intracellular, fluid indicating that rete ovarii cysts in guinea pigs are transudative in nature. A positive correlation was found between Na and Cl concentrations (r = 0.7713, P <0.0001). The mean concentrations of oestradiol (61.9 ± 17.44 pg/ml) and progesterone (2.7 ± 5.42 ng/ml) in the cyst fluid were higher than expected because the rete epithelium is not known to have steroidogenic activity. A negative correlation was found between oestradiol and progesterone concentrations in cyst fluid (r = -0.4296, P = 0.0178). Possible pathogenetic mechanisms of cystic rete ovarii in guinea pigs are discussed.
尽管豚鼠（Cavia porcellus）卵巢囊肿的发病率很高，但其病因发病机制尚不清楚。我们通过组织病理学和 CD10 抗原免疫组织化学检查了 20 只患有卵巢囊肿的豚鼠的组织样本，并测定了囊液中的 Na、K、Cl、雌二醇和孕酮浓度。在所有 20 只豚鼠中都发现了囊性卵巢网，但没有卵泡囊肿。Na（142.2±5.04mmol/l）、K（5.6±0.76mmol/l）和 Cl（116.1±5.25mmol/l）的浓度与细胞外液而非细胞内液相符，表明豚鼠卵巢网囊肿为渗出性。Na 和 Cl 浓度之间存在正相关（r=0.7713，P<0.0001）。囊液中雌二醇（61.9±17.44pg/ml）和孕酮（2.7±5.42ng/ml）的浓度高于预期，因为已知卵巢网上皮没有类固醇生成活性。囊液中雌二醇和孕酮浓度之间存在负相关（r=-0.4296，P=0.0178）。讨论了豚鼠囊性卵巢网的可能发病机制。
