British Columbia Centre on Substance Use, Vancouver, British Columbia, Canada; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada.
Vaccine. 2022 Apr 6;40(16):2442-2456. doi: 10.1016/j.vaccine.2022.02.085. Epub 2022 Mar 3.
High rates of COVID-19 vaccination uptake are required to attain community immunity. This study aims to identify factors associated with COVID-19 vaccine uncertainty and refusal among young adults, an underexplored population with regards to vaccine intention generally, in two high-income settings: Canada and France.
A cross-sectional online survey was conducted from October to December 2020 among young adults ages 18-29 years (n = 6663) living in Canada (51.9%) and France (48.1%). Multinomial logistic regression analyses were performed to identify the sociodemographic and COVID-19-related measures (e.g., prevention behavior and perspectives, health-related concerns) associated with vaccine uncertainty and refusal. We conducted weighted analyses by age, gender and province/region of residence.
Intention to accept vaccination was reported by 84.3% and 59.7% of the sample in Canada and France, respectively. Higher levels of vaccine uncertainty and refusal were observed in France compared to Canada (30.1% versus 11%, 10.2% versus 4.7%). In both countries, we found higher levels of vaccine acceptance among young adults who reported COVID-19 prevention actions. Vaccine uncertainty and refusal were associated with living in a rural area, having lower levels of educational attainment, not looking for information about COVID-19, not wearing a face mask, and reporting a lower level of concern for COVID-19's impact on family. Participants who had been tested for COVID-19 were less likely to intend to refuse a vaccine.
COVID-19 vaccine acceptance was high among young adults in Canada and France during a time in which vaccines were approved for use. Targeted interventions to build confidence in demographic groups with greater hesitance (e.g., rural and with less personal experience with COVID-19) may further boost acceptance and improve equity as vaccine efforts continue to unfold.
为了实现群体免疫，需要高比例的 COVID-19 疫苗接种率。本研究旨在确定与加拿大和法国这两个高收入国家/地区的年轻成年人 COVID-19 疫苗不确定性和拒绝接种相关的因素，而年轻人在疫苗接种意愿方面总体上是一个研究不足的群体。
2020 年 10 月至 12 月期间，对年龄在 18-29 岁的年轻人（n=6663）进行了一项横断面在线调查，他们分别居住在加拿大（51.9%）和法国（48.1%）。采用多变量逻辑回归分析，确定与疫苗不确定性和拒绝接种相关的社会人口学和 COVID-19 相关措施（例如预防行为和观点、与健康相关的担忧）。我们按年龄、性别和居住地省份/地区进行了加权分析。
加拿大和法国的样本中，分别有 84.3%和 59.7%的人表示打算接种疫苗。与加拿大相比，法国的疫苗不确定性和拒绝接种率更高（30.1%比 11%，10.2%比 4.7%）。在这两个国家，我们发现报告 COVID-19 预防措施的年轻人对疫苗的接受程度更高。疫苗不确定性和拒绝接种与居住在农村地区、教育程度较低、不寻找 COVID-19 信息、不戴口罩以及对 COVID-19 对家庭影响的担忧程度较低有关。曾接受过 COVID-19 检测的参与者不太可能打算拒绝接种疫苗。
在疫苗获准使用期间，加拿大和法国的年轻成年人对 COVID-19 疫苗的接受程度较高。针对犹豫不决的人群（例如，农村地区和个人 COVID-19 经验较少的人群），开展有针对性的干预措施，增强信心，可能会进一步提高疫苗接种率，并在疫苗接种工作持续开展的过程中，提高公平性。
